ChemicalBook CAS DataBase List 1,3-Dinitrobenzene

1,3-Dinitrobenzene synthesis

14synthesis methods

Product Name:1,3-Dinitrobenzene
CAS Number:99-65-0
Molecular formula:C6H4N2O4
Molecular Weight:168.11

1,3-Dinitrobenzene is accessible by nitration of nitrobenzene. The reaction proceeds under acid catalysis using sulfuric acid. The directing effect of the nitro group of nitrobenzene leads to 93% of the product resulting from nitration at the meta-position. The ortho- and para-products occur in only 6% and 1%, respectively.

119-26-6
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99-65-0
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$31.39/442244

Yield:99-65-0 92%

Reaction Conditions:

with dihydrogen peroxide in water at 85;Green chemistry;

Steps:

1
Take 198.6mg (1mmol) 2,4-dinitrophenylhydrazine and 1mmol H₂O₂, 5ml H₂O in 50ml single neck flask oil bath set 85 deg.] C, a reddish color system, TLC monitored the reaction, extracted three times with 10ml of dichloromethane while raw material disappeared, the combined organic phase was dried over anhydrous Na₂SO₄ Dried, filtered and the solvent was removed by rotary evaporation to give a white solid 155mg, yield 92%, purity 98%.

References:

Henan Normal University;guo, zhijun;Zhou, Hongyan;Qu, feng Bo;Zhang, Weiwei;Guo, li Bing CN103880682, 2016, B Location in patent:Paragraph 0011; 0012

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