ChemicalBook CAS DataBase List 1-Bromo-4-phenylbutane

1-Bromo-4-phenylbutane synthesis

10synthesis methods

Product Name:1-Bromo-4-phenylbutane
CAS Number:13633-25-5
Molecular formula:C10H13Br
Molecular Weight:213.11

3360-41-6
352 suppliers
$23.00/5mL

13633-25-5
229 suppliers
$8.00/1g

Yield:13633-25-5 99.6%

Reaction Conditions:

with hydrogen bromide for 12 h;Irradiation;Reflux;Reagent/catalyst;

Steps:

1.1; 1.2; 1.3 Example 11,A method for synthesizing an intermediate 1-bromo-4-phenylbutane, characterized in that the method comprises the following steps:
step 1,10 g of 4-phenylbutanol and 44 g of hydrobromic acid were sequentially added to a 250 m1 three-necked flask.2 g of POM-C3N4 catalyst, the system is light yellow and mechanically stirred.Protected from light, heated to reflux for 12 h;Step 2After the reaction, the system was yellow and viscous and cooled to room temperature.Adjust the pH of the system with saturated Na2CO3 solution = 7, stir for 30min, after liquid separation,The organic phase is extracted with dichloromethane until the aqueous layer is colorless and transparent;Step 3.After the above extract phase is dried over anhydrous sodium sulfate,The dichloromethane was evaporated to give a pale yellow product, 1-bromo-4-phenylbutane.

References:

Yang Cheng Feiyang;Yang Chengfeiyang;Chen Huaqi CN108911948, 2018, A Location in patent:Paragraph 0008; 0019; 0020; 0029

FullText

1821-12-1 Synthesis