ChemicalBook CAS DataBase List 4-Phenylbutyric acid

4-Phenylbutyric acid synthesis

13synthesis methods

Product Name:4-Phenylbutyric acid
CAS Number:1821-12-1
Molecular formula:C10H12O2
Molecular Weight:164.2

4-phenylbutyric acid is obtained by the reaction of benzene with butyrolactone in the presence of aluminum chloride, followed by neutralization with base.
Synthesis of 4-phenylbutyric acid

1008-76-0 Synthesis

1008-76-0
83 suppliers
$58.00/5g

1821-12-1
424 suppliers
$6.00/5g

Yield:1821-12-1 95%

Reaction Conditions:

with palladium 10% on activated carbon;W(OTf)₆;hydrogen at 50; under 760.051 Torr; for 12 h;

Steps:

40 Preparation of phenylbutyric acid from γ-phenyl-γ-butyrolactone

General procedure: Specific methods are as follows: propiolactone was added (0.36g, 5mmol), palladium on carbon (10%, 26.5mg, 0.025mmol, 0.5mol%) in the reactor and W (OTf)₆(107.8mg, 0.1mmol, 2mol%). A hydrogen balloon connected to the top of the reactor, and the reactor was purged with hydrogen gas atmosphere. Hydrogen atmosphere at normal pressure, the reaction was stirred at 135 deg.] C after 12h, detected by gas, γ- valerolactone complete conversion of starting material, and only n-valeric acid. The method carried out as follows completion of the hydrogenation reaction of the ring-opening reaction system separation, to obtain the desired product n-valeric acid: The reaction was completed reaction mixture was dissolved with methylene chloride, filtered to remove the palladium on carbon catalyst and W (OTf)₆99% yield measured propionic acid, purity of the product was 99%. NMR data for the product using the embodiment of the present invention is the NMR identified the product as follows:The specific reaction procedure and operation method were the same as in Example 27 except that the reaction temperature was changed to 50 ° C, and the yield 95%, the purity of the product is 99%. The product was subjected to nuclear magnetic identification using the manner described in the present invention, and the NMR data of the product were as follows

References:

CN106831389,2017,A Location in patent:Paragraph 0113; 0176-0178