![3745-79-7](/CAS/GIF/3745-79-7.gif)
1,3-THIAZOLE-4-CARBONYL CHLORIDE synthesis
- Product Name:1,3-THIAZOLE-4-CARBONYL CHLORIDE
- CAS Number:3745-79-7
- Molecular formula:C4H2ClNOS
- Molecular Weight:147.58
![4-Thiazolecarboxylic acid](/CAS/GIF/3973-08-8.gif)
3973-08-8
257 suppliers
$6.00/1g
![1,3-THIAZOLE-4-CARBONYL CHLORIDE](/CAS/GIF/3745-79-7.gif)
3745-79-7
27 suppliers
$45.00/50mg
Yield:3745-79-7 99%
Reaction Conditions:
with dichlorosulfoxide for 2 h;Heating / reflux;
Steps:
96A
Preparation 96A; Thiazole-4-carbonyl chlorideA mixture of thiazole-4-carboxylic acid (30.0 g, 232 mmol) and thionyl chloride (200 ml.) was heated at reflux for 2h. The resulting solution was evaporated and the residue dried giving a yellow solid. Yield 34.0 g, 99%. 1H NMR (CDCI3) δ 8.91 (d, 1H, J = 2 Hz)1 8.49 (d, 1H, J = 2 Hz).
References:
WO2008/4117,2008,A1 Location in patent:Page/Page column 161