4-Thiazolecarboxylic acid synthesis
- Product Name:4-Thiazolecarboxylic acid
- CAS Number:3973-08-8
- Molecular formula:C4H3NO2S
- Molecular Weight:129.14
693-95-8
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3973-08-8
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Yield:3973-08-8 70.2%
Reaction Conditions:
with potassium permanganate in water at 55; for 22 h;Reagent/catalyst;Temperature;
Steps:
3.3.4 3.4) Synthesis thiazole-4- carboxylic acid
4-methylthiazole (19.8 g, 0.2 mol),200 mL of water and potassium permanganate (173.8 g, 1.1 mol) were placed in a 500 mL three-neck reaction flask and heated to 55° C. for 22 h with stirring and heating.The reaction solution was then cooled and then filtered. The filter cake (manganese dioxide) was washed with hot water at 50°C, and the filtrate was adjusted to pH 3 with dilute hydrochloric acid.A solid precipitated and was filtered. The filter cake was washed with a small amount of water. The product was dried to give 18.1 g, yield 70.2%, melting point 196-198°C.
References:
Yantai Beisen Pharmaceutical Technology Co., Ltd.;Bi Haidong;Zhi Caixia;Zhang Yixing CN104557902, 2018, B Location in patent:Paragraph 0063; 0076; 0081; 0088; 0089; 0102
59418-09-6
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3973-08-8
258 suppliers
$6.00/1g
22358-80-1
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3973-08-8
258 suppliers
$6.00/1g