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ChemicalBook >> CAS DataBase List >> Eltrombopag

Eltrombopag

Eltrombopag price.
  • $8 - $3686
  • Product name: Eltrombopag
  • CAS: 496775-61-2
  • MF: C25H22N4O4
  • MW: 442.47
  • EINECS:610-469-9
  • MDL Number:MFCD20926253
  • Synonyms:(1,1'-Biphenyl)-3-carboxylic acid, 3'-((2Z)-(1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene)hydrazino)-2'-hydroxy-;Sb497115;Sb-497115;Unii-S56D65xj9g;(E)-3\'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2\'-hydroxybiphenyl-3-carboxylic acid;Eltrombopag;3'-[2-[(2Z)-1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid;3-(5-{2-[2-(3,4-diMethylphenyl)-5-Methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]hydrazin-1-ylidene}-6-oxocyclohexa-1,3-dien-1-yl)benzoic acid
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  • AK Scientific
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  • ApexBio Technology
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  • ManufacturerAK Scientific
  • Product numberJ52723
  • Product descriptionEltrombopag
  • Packaging100mg
  • Price$245
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX5021
  • Product descriptionEltrombopag
  • Packaging50mg
  • Price$254
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA157281
  • Product description(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+%
  • Packaging10mg
  • Price$8
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA157281
  • Product description(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+%
  • Packaging50mg
  • Price$14
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA157281
  • Product description(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+%
  • Packaging100mg
  • Price$26
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA157281
  • Product description(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+%
  • Packaging250mg
  • Price$38
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA157281
  • Product description(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+%
  • Packaging1g
  • Price$95
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA157281
  • Product description(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+%
  • Packaging5g
  • Price$291
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA157281
  • Product description(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+%
  • Packaging25g
  • Price$969
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0005198
  • Product descriptionELTROMBOPAG 95.00%
  • Packaging5MG
  • Price$265.1
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0005198
  • Product descriptionELTROMBOPAG 95.00%
  • Packaging50MG
  • Price$2194.5
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB2159
  • Product descriptionEltrombopag
  • Packaging10mg
  • Price$70
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number3013A
  • Product descriptionEltrombopag
  • Packaging10mg
  • Price$75
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number3013A
  • Product descriptionEltrombopag
  • Packaging25mg
  • Price$109
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number3013A
  • Product descriptionEltrombopag
  • Packaging100mg
  • Price$229
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number3013A
  • Product descriptionEltrombopag
  • Packaging1g
  • Price$490
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J52723 Eltrombopag 100mg $245 2021-12-16 Buy
AK Scientific X5021 Eltrombopag 50mg $254 2021-12-16 Buy
Ambeed A157281 (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+% 10mg $8 2021-12-16 Buy
Ambeed A157281 (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+% 50mg $14 2021-12-16 Buy
Ambeed A157281 (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+% 100mg $26 2021-12-16 Buy
Ambeed A157281 (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+% 250mg $38 2021-12-16 Buy
Ambeed A157281 (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+% 1g $95 2021-12-16 Buy
Ambeed A157281 (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+% 5g $291 2021-12-16 Buy
Ambeed A157281 (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+% 25g $969 2021-12-16 Buy
American Custom Chemicals Corporation API0005198 ELTROMBOPAG 95.00% 5MG $265.1 2021-12-16 Buy
American Custom Chemicals Corporation API0005198 ELTROMBOPAG 95.00% 50MG $2194.5 2021-12-16 Buy
ApexBio Technology B2159 Eltrombopag 10mg $70 2021-12-16 Buy
AvaChem 3013A Eltrombopag 10mg $75 2021-12-16 Buy
AvaChem 3013A Eltrombopag 25mg $109 2021-12-16 Buy
AvaChem 3013A Eltrombopag 100mg $229 2021-12-16 Buy
AvaChem 3013A Eltrombopag 1g $490 2021-12-16 Buy

Properties

Melting point :242-244°C
Boiling point :656.8±65.0 °C(Predicted)
Density :1.33
storage temp. :Keep in dark place,Inert atmosphere,Room temperature
solubility :Soluble in DMSO (up to 55 mg/ml) or in ethanol (up to 14 mg/ml).
form :solid
pka :-1.26±0.40(Predicted)
color :Orange
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI :InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,26,30H,1-3H3,(H,32,33)/b27-22-
InChIKey :XDXWLKQMMKQXPV-QYQHSDTDSA-N
SMILES :C1(C2=CC=CC(N/N=C3\C(=O)N(C4=CC=C(C)C(C)=C4)N=C\3C)=C2O)=CC=CC(C(O)=O)=C1

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P314 Get medical advice/attention if you feel unwell.
P330 Rinse mouth.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

ITP is an autoimmune disease in which antiplatelet antibodies accelerate the destruction of platelets. In addition, platelet production can be impaired because the antiplatelet antibodies can also damage megakaryocytes. Although the thrombocytopenia of ITP can be severe, signs of bleeding are usually only minor.
Eltrombopag is an oral, small-molecule, nonpeptide TPO-receptor agonist. It initiates TPO-receptor signaling by interacting with the transmembrane domain of the receptor, thereby inducing proliferation and differentiation of cells in the megakaryocytic lineage. Eltrombopag is the second TPO-receptor agonist to reach the market behind romiplostim (Nplate), a recombinant fusion protein launched in 2008. Both drugs are specifically indicated for the treatment of thrombocytopenia in patients with chronic ITP who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. Eltrombopag is supplied as the ethanolamine salt (also known as eltrombopag olamine).
The most common adverse reactions associated with eltrombopag were nausea, vomiting, mennorrhagia, myalgia, paresthesia and cataracts. Eltrombopag is derived in five synthetic steps starting from 2-bromo-6-nitroanisole, via Suzuki coupling reaction with 3-carboxyphenylboronic acid to a biphenyl intermediate, followed by cleavage of the methyl ether moiety with hydrobromic acid, and reduction of the nitro group to an amino group under catalytic hydrogenation conditions. Subsequently, the amino group is diazotized with sodium nitrite and hydrochloric acid, and the diazonium intermediate is condensed with 1-(3,4-dimethylphenyl)-3-methyl-2,5-dihydro-1H-pyrazol-5-one to produce eltrombopag.

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