WZ4003
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- $32 - $1025
- Product name: WZ4003
- CAS: 1214265-58-3
- MF: C25H29ClN6O3
- MW: 496.99
- EINECS:
- MDL Number:MFCD28015100
- Synonyms:Propanamide, N-[3-[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-;WZ4003;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]propanamide;N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide;N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]propanamide;WZ 4003;WZ4003;CS-1174;WZ 4003, NUAK kinase inhibitor
27 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 25mg
- 10
- 10mg
- 1mg
- 5mg
- 50
- 10mM(in 1mL DMSO)
- 2x25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number2806AH
- Product descriptionN-[3-[5-Chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]propanamide
- Packaging50mg
- Price$703
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1374
- Product descriptionWZ4003
- Packaging5mg
- Price$68
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1374
- Product descriptionWZ4003
- Packaging10mM(in 1mL DMSO)
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1374
- Product descriptionWZ4003
- Packaging50mg
- Price$399
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2385
- Product descriptionWZ4003 99%
- Packaging25mg
- Price$308
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2385
- Product descriptionWZ4003 99%
- Packaging2x25mg
- Price$462
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19177
- Product descriptionWZ4003 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19177
- Product descriptionWZ4003 ≥98%
- Packaging5mg
- Price$100
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19177
- Product descriptionWZ4003 ≥98%
- Packaging10mg
- Price$184
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19177
- Product descriptionWZ4003 ≥98%
- Packaging25mg
- Price$381
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM167551
- Product descriptionN-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide 98%
- Packaging10mg
- Price$142
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM167551
- Product descriptionN-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide 98%
- Packaging50mg
- Price$410
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3258
- Product descriptionWZ4003 98.14%
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3258
- Product descriptionWZ4003 98.14%
- Packaging10mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3258
- Product descriptionWZ4003 98.14%
- Packaging50mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004259
- Product descriptionWZ4003 98+%
- Packaging25mg
- Price$262
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2806AH | N-[3-[5-Chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]propanamide | 50mg | $703 | 2021-12-16 | Buy |
| ApexBio Technology | B1374 | WZ4003 | 5mg | $68 | 2021-12-16 | Buy |
| ApexBio Technology | B1374 | WZ4003 | 10mM(in 1mL DMSO) | $110 | 2021-12-16 | Buy |
| ApexBio Technology | B1374 | WZ4003 | 50mg | $399 | 2021-12-16 | Buy |
| Axon Medchem | Axon2385 | WZ4003 99% | 25mg | $308 | 2021-12-16 | Buy |
| Axon Medchem | Axon2385 | WZ4003 99% | 2x25mg | $462 | 2021-12-16 | Buy |
| Cayman Chemical | 19177 | WZ4003 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19177 | WZ4003 ≥98% | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 19177 | WZ4003 ≥98% | 10mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 19177 | WZ4003 ≥98% | 25mg | $381 | 2024-03-01 | Buy |
| Chemenu | CM167551 | N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide 98% | 10mg | $142 | 2021-12-16 | Buy |
| Chemenu | CM167551 | N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide 98% | 50mg | $410 | 2021-12-16 | Buy |
| ChemScene | CS-3258 | WZ4003 98.14% | 5mg | $50 | 2021-12-16 | Buy |
| ChemScene | CS-3258 | WZ4003 98.14% | 10mg | $80 | 2021-12-16 | Buy |
| ChemScene | CS-3258 | WZ4003 98.14% | 50mg | $200 | 2021-12-16 | Buy |
| Crysdot | CD31004259 | WZ4003 98+% | 25mg | $262 | 2021-12-16 | Buy |
Properties
Density :1.303±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :insoluble in H2O; ≥2.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥7.85 mg/mL in DMSO with gentle warming
pka :14.27±0.70(Predicted)
form :powder
color :white to beige
storage temp. :-20°C
solubility :insoluble in H2O; ≥2.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥7.85 mg/mL in DMSO with gentle warming
pka :14.27±0.70(Predicted)
form :powder
color :white to beige
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
NUAK1 (also known as AMPK-related kinase 5) and NUAK2 (also known as SNF1/AMPK-related kinase) are members of the AMP-activated protein kinase (AMPK) family of protein kinases that are activated by the liver kinase B1 tumor suppressor kinase. NUAK kinases are thought to have roles in regulating cell adhesion, cancer cell invasion, embryonic development, senescence, proliferation, neuronal polarity, and axon branching. WZ4003 is a selective inhibitor of NUAK1 and NUAK2 (IC50s = 20 and 100 nM, respectively). It does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. At 3-10 μM, WZ4003 has been shown to inhibit the phosphorylation of the NUAK1 substrate, myosin phosphate-targeting subunit 1 at Ser445. When administered to mouse embryonic fibroblasts in vitro, 10 μM WZ4003 inhibits proliferation and migration in a wound-healing assay. It has also been shown to impair the invasive potential of U2OS cells at similar concentrations in a 3D cell invasion assay.More related product prices
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