RETAPAMULIN
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- $5 - $1912
- Product name: RETAPAMULIN
- CAS: 224452-66-8
- MF: C30H47NO4S
- MW: 517.76
- EINECS:639-491-7
- MDL Number:MFCD11045316
- Synonyms:RETAPAMULIN;RetapaMulin (SB-275833);(3aS,4R,5S,6S,8R,9R,9aR,10R)-2-(exo-8-Methyl-8-azabicyclo[3.2.1]octan-3-ylsulfanyl)acetic acid 5-hydroxy-4,6,9,10-tetraMethyl-1-oxo-6-vinylperhydro-3a,9-propanocyclopentacycloocten-8-yl ester;RetapaMulin API;tetapaMulin;(1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetraMethyl-9-oxotricyclo[5.4.3.0^{1,8}]tetradecan-6-yl 2-{[(1R,3S,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl]sulfanyl}acetate;Rebapamulin;SB-275833
22 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- 5g
- 10G
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product numberJ10910
- Product descriptionRetapamulin
- Packaging10mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA195059
- Product descriptionRetapamulin 97+%
- Packaging5mg
- Price$5
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA195059
- Product descriptionRetapamulin 97+%
- Packaging10mg
- Price$6
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA195059
- Product descriptionRetapamulin 97+%
- Packaging250mg
- Price$30
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA195059
- Product descriptionRetapamulin 97+%
- Packaging1g
- Price$79
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA195059
- Product descriptionRetapamulin 97+%
- Packaging5g
- Price$253
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005738
- Product descriptionRETAPAMULIN 95.00%
- Packaging1G
- Price$798
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005738
- Product descriptionRETAPAMULIN 95.00%
- Packaging10G
- Price$1912
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2019
- Product descriptionRetapamulin
- Packaging10mg
- Price$84
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2019
- Product descriptionRetapamulin
- Packaging10mM(in 1mL DMSO)
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146178
- Product descriptionRetapamulin >99%
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146178
- Product descriptionRetapamulin >99%
- Packaging1g
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number21528
- Product descriptionRetapamulin ≥99%
- Packaging1mg
- Price$62
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21528
- Product descriptionRetapamulin ≥99%
- Packaging5mg
- Price$270
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21528
- Product descriptionRetapamulin ≥99%
- Packaging10mg
- Price$477
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21528
- Product descriptionRetapamulin ≥99%
- Packaging25mg
- Price$1041
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | J10910 | Retapamulin | 10mg | $96 | 2021-12-16 | Buy |
| Ambeed | A195059 | Retapamulin 97+% | 5mg | $5 | 2021-12-16 | Buy |
| Ambeed | A195059 | Retapamulin 97+% | 10mg | $6 | 2021-12-16 | Buy |
| Ambeed | A195059 | Retapamulin 97+% | 250mg | $30 | 2021-12-16 | Buy |
| Ambeed | A195059 | Retapamulin 97+% | 1g | $79 | 2021-12-16 | Buy |
| Ambeed | A195059 | Retapamulin 97+% | 5g | $253 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005738 | RETAPAMULIN 95.00% | 1G | $798 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005738 | RETAPAMULIN 95.00% | 10G | $1912 | 2021-12-16 | Buy |
| ApexBio Technology | B2019 | Retapamulin | 10mg | $84 | 2021-12-16 | Buy |
| ApexBio Technology | B2019 | Retapamulin | 10mM(in 1mL DMSO) | $88 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146178 | Retapamulin >99% | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146178 | Retapamulin >99% | 1g | $1802 | 2021-12-16 | Buy |
| Cayman Chemical | 21528 | Retapamulin ≥99% | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 21528 | Retapamulin ≥99% | 5mg | $270 | 2024-03-01 | Buy |
| Cayman Chemical | 21528 | Retapamulin ≥99% | 10mg | $477 | 2024-03-01 | Buy |
| Cayman Chemical | 21528 | Retapamulin ≥99% | 25mg | $1041 | 2024-03-01 | Buy |
Properties
Boiling point :594.9±50.0 °C(Predicted)
Density :1.16±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :insoluble in H2O; ≥114.8 mg/mL in EtOH; ≥16.15 mg/mL in DMSO
form :solid
pka :14.65±0.70(Predicted)
color :White to off-white
InChIKey :STZYTFJPGGDRJD-IFPFAXJDNA-N
CAS DataBase Reference :224452-66-8(CAS DataBase Reference)
Density :1.16±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :insoluble in H2O; ≥114.8 mg/mL in EtOH; ≥16.15 mg/mL in DMSO
form :solid
pka :14.65±0.70(Predicted)
color :White to off-white
InChIKey :STZYTFJPGGDRJD-IFPFAXJDNA-N
CAS DataBase Reference :224452-66-8(CAS DataBase Reference)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Antibacterial retapamulin is a derivative of the natural product pleuromutilin and was developed by Glaxo and approved in the US in 2007 for the treatment of skin infections. It has a unique mechanism of action, inhibiting bacterial protein synthesis by inhibiting the larger subunit of the ribosome, and thus has no cross resistance to other antibacterial agents. Pleuromutilin is a tricyclic diterpenoid that was first isolated in 1951 from the edible mushroom Pleurotus mutilus. The first semisynthetic analogs tiamulin and valnemulin, developed for veterinary use, have been shown to interact uniquely with bacterial ribosomes by high affinity binding to a site on the 50S subunit. Binding to this site interferes with ribosomal peptidyl transferase activity, blocks P-site interactions, and prevents the evolution of active 50S ribosomal subunits. Retapamulin, the first pleuromutilin approved for human use, behaves similarly to selectively inhibit bacterial protein synthesis. This novel mechanism of action has been implicated in the lack of in vitro target-specific cross-resistance with other classes of antibiotics.More related product prices
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