P 22077
|
- $78 - $1802
- Product name: P 22077
- CAS: 1247819-59-5
- MF: C12H7F2NO3S2
- MW: 315.32
- EINECS:
- MDL Number:MFCD22580421
- Synonyms:P 22077;1-(5-(2,4-difluorophenylthio)-4-nitrothiophen-2-yl)ethanone;1-[5-[(2,4-Difluorophenyl)thio]-4-n-itro-2-thienyl]-ethanone;Ethanone, 1-[5-[(2,4-difluorophenyl)thio]-4-nitro-2-thienyl]-;1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]ethanone P 22077;P 22077 1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]ethanone;1-[5-(2,4-Difluoro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone;CS-1115
27 prices
Selected condition：
Brand
- Acints
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Tocris
- TRC
- Usbiological
Package
- 100mg
- 10
- 250mg
- 1000mg
- 50
- 10mg
- 50mg
- 1g
- 5g
- 10mM(in 1mL DMSO)
- ManufacturerAcints
- Product numberACI-02003
- Product description1-[5-(2,4-Difluoro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone 95%+
- Packaging5g
- Price$1297.75
- Updated2021-12-16
- Buy
- ManufacturerAcints
- Product numberACI-02003
- Product description1-[5-(2,4-Difluoro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone 95%+
- Packaging1g
- Price$427.75
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2624AH
- Product description1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]-ethanone
- Packaging50mg
- Price$442
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2624AH
- Product description1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]-ethanone
- Packaging10mg
- Price$163
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001523
- Product descriptionP-22077 95.00%
- Packaging10MG
- Price$245.7
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8198
- Product descriptionP22077
- Packaging50mg
- Price$260
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8198
- Product descriptionP22077
- Packaging10mM(in 1mL DMSO)
- Price$86
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8198
- Product descriptionP22077
- Packaging10mg
- Price$78
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1906
- Product descriptionP22077 99%
- Packaging10mg
- Price$104.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546205
- Product descriptionP22077 >98%
- Packaging10mg
- Price$181.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546205
- Product descriptionP22077 >98%
- Packaging50mg
- Price$472.6
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181076
- Product descriptionP22077 >98%
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181076
- Product descriptionP22077 >98%
- Packaging1000mg
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM200006
- Product description1-[5-(2,4-Difluoro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone 98%
- Packaging100mg
- Price$391
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1860
- Product descriptionP22077 99.97%
- Packaging100mg
- Price$523
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1860
- Product descriptionP22077 99.97%
- Packaging50mg
- Price$354
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Acints | ACI-02003 | 1-[5-(2,4-Difluoro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone 95%+ | 5g | $1297.75 | 2021-12-16 | Buy |
| Acints | ACI-02003 | 1-[5-(2,4-Difluoro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone 95%+ | 1g | $427.75 | 2021-12-16 | Buy |
| AK Scientific | 2624AH | 1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]-ethanone | 50mg | $442 | 2021-12-16 | Buy |
| AK Scientific | 2624AH | 1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]-ethanone | 10mg | $163 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001523 | P-22077 95.00% | 10MG | $245.7 | 2021-12-16 | Buy |
| ApexBio Technology | A8198 | P22077 | 50mg | $260 | 2021-12-16 | Buy |
| ApexBio Technology | A8198 | P22077 | 10mM(in 1mL DMSO) | $86 | 2021-12-16 | Buy |
| ApexBio Technology | A8198 | P22077 | 10mg | $78 | 2021-12-16 | Buy |
| Axon Medchem | Axon1906 | P22077 99% | 10mg | $104.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546205 | P22077 >98% | 10mg | $181.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546205 | P22077 >98% | 50mg | $472.6 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181076 | P22077 >98% | 250mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181076 | P22077 >98% | 1000mg | $1802 | 2021-12-16 | Buy |
| Chemenu | CM200006 | 1-[5-(2,4-Difluoro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone 98% | 100mg | $391 | 2021-12-16 | Buy |
| ChemScene | CS-1860 | P22077 99.97% | 100mg | $523 | 2021-12-16 | Buy |
| ChemScene | CS-1860 | P22077 99.97% | 50mg | $354 | 2021-12-16 | Buy |
Properties
Melting point :146 - 148°C
Boiling point :395.4±42.0 °C(Predicted)
Density :1.53±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 25 mg/ml)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Boiling point :395.4±42.0 °C(Predicted)
Density :1.53±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 25 mg/ml)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
| Symbol(GHS): |
  
|
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Danger | ||||||||||||||||||||||||||||
| Hazard statements: |
|
||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
P22077 (1247819-59-5) is a selective (tested against 23 other DUBs) inhibitor of USP7 (IC50?= 8 μM) and the closely related USP47.1,2?It destabilizes claspin, a scaffolding protein involved in regulating Chk1 kinase, a DNA damage response enzyme.2?P22077 inhibits neuroblastoma growth?via?induction of p53-mediated apoptosis.3?N-Myc was destabilized by P22077 inhibition of USP7 in human neuroblastoma cells.4?It was able to stabilize p53 levels in conjunction with an Mdm2 inhibitor (Nutlin-3,?Cat# 10-1350)?in HCT116 colorectal carcinoma cells.5More related product prices
Thalidomide P-5091 TCID WP1130 PR-619 BAY 11-7082 Brefeldin A AAL-993 AG 490 461054-93-3Related product price
- Thalidomide
$7-1767.15 - P-5091
$28-1802 - TCID
$55-4150
