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ChemicalBook >> CAS DataBase List >> Lorlatinib

Lorlatinib

Lorlatinib price.
  • $37 - $1335
  • Product name: Lorlatinib
  • CAS: 1454846-35-5
  • MF: C21H19FN6O2
  • MW: 406.41
  • EINECS:813-704-5
  • MDL Number:
  • Synonyms:(10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile;Lorlatinib,PF-06463922;PF-06463922, Lorlatinib;(R)-26-amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile;Lorlatinib(PF0643922);High Purity API Lorlatinib;Anaplastic lymphoma kinase (ALK);Lorlatinib Powder
29 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Axon Medchem
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
Package
  • 5mg
  • 10mM(in 1mL DMSO)
  • 1mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number2641AH
  • Product description(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile
  • Packaging5mg
  • Price$136
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2641AH
  • Product description(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile
  • Packaging10mg
  • Price$176
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2641AH
  • Product description(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile
  • Packaging25mg
  • Price$254
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2641AH
  • Product description(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile
  • Packaging100mg
  • Price$359
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2641AH
  • Product description(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile
  • Packaging250mg
  • Price$660
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA231019
  • Product description(R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+%
  • Packaging5mg
  • Price$62
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA231019
  • Product description(R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+%
  • Packaging10mg
  • Price$87
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA231019
  • Product description(R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+%
  • Packaging25mg
  • Price$106
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA231019
  • Product description(R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+%
  • Packaging50mg
  • Price$139
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA231019
  • Product description(R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+%
  • Packaging100mg
  • Price$222
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA231019
  • Product description(R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+%
  • Packaging250mg
  • Price$445
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA231019
  • Product description(R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+%
  • Packaging1g
  • Price$1335
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4882
  • Product descriptionPF-06463922
  • Packaging5mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4882
  • Product descriptionPF-06463922
  • Packaging10mM(in 1mL DMSO)
  • Price$83
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4882
  • Product descriptionPF-06463922
  • Packaging25mg
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2600
  • Product descriptionPF06463922-Lorlatinib 99%
  • Packaging25mg
  • Price$423.5
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2641AH (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile 5mg $136 2021-12-16 Buy
AK Scientific 2641AH (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile 10mg $176 2021-12-16 Buy
AK Scientific 2641AH (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile 25mg $254 2021-12-16 Buy
AK Scientific 2641AH (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile 100mg $359 2021-12-16 Buy
AK Scientific 2641AH (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-H][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile 250mg $660 2021-12-16 Buy
Ambeed A231019 (R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+% 5mg $62 2021-12-16 Buy
Ambeed A231019 (R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+% 10mg $87 2021-12-16 Buy
Ambeed A231019 (R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+% 25mg $106 2021-12-16 Buy
Ambeed A231019 (R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+% 50mg $139 2021-12-16 Buy
Ambeed A231019 (R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+% 100mg $222 2021-12-16 Buy
Ambeed A231019 (R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+% 250mg $445 2021-12-16 Buy
Ambeed A231019 (R)-26-Amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile 98+% 1g $1335 2021-12-16 Buy
ApexBio Technology B4882 PF-06463922 5mg $65 2021-12-16 Buy
ApexBio Technology B4882 PF-06463922 10mM(in 1mL DMSO) $83 2021-12-16 Buy
ApexBio Technology B4882 PF-06463922 25mg $240 2021-12-16 Buy
Axon Medchem Axon2600 PF06463922-Lorlatinib 99% 25mg $423.5 2021-12-16 Buy

Properties

Melting point :184-187°C
Boiling point :675.0±55.0 °C(Predicted)
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :Chloroform (Slightly), Ethyl Acetate (Slightly)
form :Solid
pka :6.05±0.40(Predicted)
color :White to Off-White
Stability :Hygroscopic
InChI :InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1
InChIKey :IIXWYSCJSQVBQM-LLVKDONJSA-N
SMILES :[C@@H]1(C)C2=CC(F)=CC=C2C(=O)N(C)CC2=NN(C)C(C#N)=C2C2C=C(C(N)=NC=2)O1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P314 Get medical advice/attention if you feel unwell.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. PF-06463922 is an ATP-competitive, selective inhibitor of ALK (Ki = < 0.07 nM) and c-Ros oncogene 1 (ROS1, Ki = 0.7 nM). It has strong activity against all known ALK and ROS1 mutants identified in patients, including the EML4-L1196M mutant of ALK (Ki = < 0.02 nM). PF-06463922 is orally available, displaying inhibition of ALK phosphorylation and antitumor efficacy in a xenograft model expressing EML4-L1196M ALK. It demonstrates efficient blood-brain barrier penetration, produces brain tumor regression in mice harboring EML4-ALK tumors, and increases overall survival.