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ChemicalBook >> CAS DataBase List >> LY 2784544

LY 2784544

LY 2784544 price.
  • $62 - $9556.47
  • Product name: LY 2784544
  • CAS: 1229236-86-5
  • MF: C23H25ClFN7O
  • MW: 469.94
  • EINECS:-0
  • MDL Number:MFCD20482143
  • Synonyms:LY2784544(gandotinib);3-(4-Chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[;3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine;LY 2784544;3-[(4-Chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine;3-(4-chloro-2-fluorobenzyl)-2-Methyl-N-(3-Methyl-1H-pyrazol-5-yl)-8-(MorpholinoMethyl)iMidazo[1,2-b]pyridazin-6-aMine;LY2784544/LY-2784544;IMidazo[1,2-b]pyridazin-6-aMine, 3-[(4-chloro-2-fluorophenyl)Methyl]-2-Methyl-N-(5-Methyl-1H-pyrazol-3-yl)-8-(4-MorpholinylMethyl)-
29 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 5mg
  • 10mM(in 1mL DMSO)
  • 1MG
  • 10MG
  • 25mg
  • 50mg
  • 100mg
  • 1G
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1196-M050
  • Product descriptionLY2784544 ≥95%
  • Packaging50mg
  • Price$961
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1196
  • Product descriptionLY2784544
  • Packaging100mg
  • Price$1470
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000940
  • Product descriptionLY-2784544 95.00%
  • Packaging1MG
  • Price$216.3
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000940
  • Product descriptionLY-2784544 95.00%
  • Packaging10MG
  • Price$1006.58
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000940
  • Product descriptionLY-2784544 95.00%
  • Packaging50MG
  • Price$1855.51
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000940
  • Product descriptionLY-2784544 95.00%
  • Packaging1G
  • Price$9556.47
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4147
  • Product descriptionLY2784544
  • Packaging10mM(in 1mL DMSO)
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2554
  • Product descriptionLY2784544-Gandotinib 99%
  • Packaging5mg
  • Price$104.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFL103868
  • Product descriptionLY 2784544
  • Packaging10mg
  • Price$175
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFL103868
  • Product descriptionLY 2784544
  • Packaging50mg
  • Price$612.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16705
  • Product descriptionLY2784544 ≥98%
  • Packaging1mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16705
  • Product descriptionLY2784544 ≥98%
  • Packaging5mg
  • Price$135
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16705
  • Product descriptionLY2784544 ≥98%
  • Packaging10mg
  • Price$239
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16705
  • Product descriptionLY2784544 ≥98%
  • Packaging25mg
  • Price$522
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0426
  • Product descriptionGandotinib 99.96%
  • Packaging5mg
  • Price$132
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0426
  • Product descriptionGandotinib 99.96%
  • Packaging10mg
  • Price$228
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1196-M050 LY2784544 ≥95% 50mg $961 2021-12-16 Buy
AK Scientific SYN1196 LY2784544 100mg $1470 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000940 LY-2784544 95.00% 1MG $216.3 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000940 LY-2784544 95.00% 10MG $1006.58 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000940 LY-2784544 95.00% 50MG $1855.51 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000940 LY-2784544 95.00% 1G $9556.47 2021-12-16 Buy
ApexBio Technology A4147 LY2784544 10mM(in 1mL DMSO) $120 2021-12-16 Buy
Axon Medchem Axon2554 LY2784544-Gandotinib 99% 5mg $104.5 2021-12-16 Buy
Biosynth Carbosynth FL103868 LY 2784544 10mg $175 2021-12-16 Buy
Biosynth Carbosynth FL103868 LY 2784544 50mg $612.5 2021-12-16 Buy
Cayman Chemical 16705 LY2784544 ≥98% 1mg $62 2024-03-01 Buy
Cayman Chemical 16705 LY2784544 ≥98% 5mg $135 2024-03-01 Buy
Cayman Chemical 16705 LY2784544 ≥98% 10mg $239 2024-03-01 Buy
Cayman Chemical 16705 LY2784544 ≥98% 25mg $522 2024-03-01 Buy
ChemScene CS-0426 Gandotinib 99.96% 5mg $132 2021-12-16 Buy
ChemScene CS-0426 Gandotinib 99.96% 10mg $228 2021-12-16 Buy

Properties

Density :1.45
storage temp. :Store at -20°C
solubility :≥23.5 mg/mL in DMSO; insoluble in H2O; ≥5.65 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :14.12±0.10(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

LY2784544 is a potent, ATP-competitive inhibitor of janus kinase 2 (JAK2) that less effectively inhibits JAK3 (IC50s = 3 and 48 nM, respectively). It also inhibits JAK2 containing the V617F mutation (IC50 = 20 nM), blocking STAT5 phosphorylation and proliferation of Ba/F3 pro-B-cells expressing this constitutively active JAK2 mutant form. When given by oral gavage, LY2784544 significantly reduces the growth of Ba/F3 pro-B-cells in SCID mice without affecting erythroid progenitors, reticulocytes, or platelets. JAK inhibitors, including LY2784544, may be useful in hematological malignancies.

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