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ChemicalBook >> CAS DataBase List >> LOXO-101

LOXO-101

LOXO-101 price.
  • $30 - $1300
  • Product name: LOXO-101
  • CAS: 1223403-58-4
  • MF: C21H22F2N6O2
  • MW: 428.44
  • EINECS:
  • MDL Number:MFCD28902192
  • Synonyms:LOXO-101;(R)-N-(5-((S)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide;ARRY 470;(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide;LOXO-101 (ARRY-470);CS-2322;LOXO101;LOXO 101; LOXO-101 Larotrectinib
26 prices
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Brand
  • ACHEMBLOCK
  • AK Scientific
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
  • Usbiological
Package
  • 1mg
  • 5MG
  • 10mg
  • 25MG
  • 50mg
  • 100mg
  • 250mg
  • 1G
  • ManufacturerACHEMBLOCK
  • Product numberH-8992
  • Product description(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide 97%
  • Packaging5MG
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberH-8992
  • Product description(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide 97%
  • Packaging25MG
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberH-8992
  • Product description(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide 97%
  • Packaging1G
  • Price$1150
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3482DG
  • Product descriptionLarotrectinib
  • Packaging50mg
  • Price$522
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611598
  • Product descriptionLOXO-101
  • Packaging100mg
  • Price$414.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611598
  • Product descriptionLOXO-101
  • Packaging250mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611598
  • Product descriptionLOXO-101
  • Packaging1g
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD145150
  • Product descriptionLarotrectinib
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD145150
  • Product descriptionLarotrectinib
  • Packaging10mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD145150
  • Product descriptionLarotrectinib
  • Packaging25mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD145150
  • Product descriptionLarotrectinib
  • Packaging50mg
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD145150
  • Product descriptionLarotrectinib
  • Packaging100mg
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number27056
  • Product descriptionLOXO-101
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27056
  • Product descriptionLOXO-101
  • Packaging5mg
  • Price$151
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27056
  • Product descriptionLOXO-101
  • Packaging10mg
  • Price$278
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27056
  • Product descriptionLOXO-101
  • Packaging25mg
  • Price$638
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ACHEMBLOCK H-8992 (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide 97% 5MG $30 2021-12-16 Buy
ACHEMBLOCK H-8992 (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide 97% 25MG $95 2021-12-16 Buy
ACHEMBLOCK H-8992 (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide 97% 1G $1150 2021-12-16 Buy
AK Scientific 3482DG Larotrectinib 50mg $522 2021-12-16 Buy
Biorbyt Ltd orb611598 LOXO-101 100mg $414.8 2021-12-16 Buy
Biorbyt Ltd orb611598 LOXO-101 250mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb611598 LOXO-101 1g $1208.7 2021-12-16 Buy
Biosynth Carbosynth FD145150 Larotrectinib 5mg $50 2021-12-16 Buy
Biosynth Carbosynth FD145150 Larotrectinib 10mg $90 2021-12-16 Buy
Biosynth Carbosynth FD145150 Larotrectinib 25mg $200 2021-12-16 Buy
Biosynth Carbosynth FD145150 Larotrectinib 50mg $350 2021-12-16 Buy
Biosynth Carbosynth FD145150 Larotrectinib 100mg $500 2021-12-16 Buy
Cayman Chemical 27056 LOXO-101 1mg $44 2024-03-01 Buy
Cayman Chemical 27056 LOXO-101 5mg $151 2024-03-01 Buy
Cayman Chemical 27056 LOXO-101 10mg $278 2024-03-01 Buy
Cayman Chemical 27056 LOXO-101 25mg $638 2024-03-01 Buy

Properties

Density :1.55±0.1 g/cm3(Predicted)
storage temp. :RT
solubility :Soluble in DMSO (up to 5 mg/ml).
form :solid
pka :8.41±0.40(Predicted)
color :Yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

LOXO-101 is an inhibitor of the tropomyosin-related kinases TrkA, TrkB, and TrkC (IC50s = 2-20 nM). It is selective for TrkA, -B, and -C over a panel of 226 kinases at 1 μM. LOXO-101 inhibits the growth of CUTO-3.29, KM12, and MO-91 patient-derived cancer cell lines (IC50s = <100, <10, and <10 nM, respectively). In vivo, LOXO-101 (60 and 200 mg/kg) reduces tumor growth in a KM12 mouse xenograft model.

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