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ChemicalBook >> CAS DataBase List >> LGK-974

LGK-974

LGK-974 price.
  • $37 - $4090
  • Product name: LGK-974
  • CAS: 1243244-14-5
  • MF: C23H20N6O
  • MW: 396.44
  • EINECS:
  • MDL Number:MFCD27501026
  • Synonyms:LGK974(NVP-LGK974);2-[5-Methyl-6-(2-methyl-4-pyridyl)-3-pyridyl]-N-(5-pyrazin-2-yl-2-pyridyl)acetamide;LGK-974;2-(2',3-diMethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetaMide;2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide;[2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-;NVP-LGK974;LGK-974 2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide
27 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 500μg
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 10mM(in 1mL DMSO)
  • 100mg
  • 250mg
  • 1g
  • 1000mg
  • ManufacturerAK Scientific
  • Product number2140AH
  • Product description2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide
  • Packaging1g
  • Price$4090
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2307
  • Product descriptionLGK-974
  • Packaging5mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2307
  • Product descriptionLGK-974
  • Packaging10mM(in 1mL DMSO)
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2307
  • Product descriptionLGK-974
  • Packaging50mg
  • Price$640
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60103
  • Product descriptionLGK-974(WNT974) ≥98%
  • Packaging10mg
  • Price$358
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181048
  • Product descriptionLGK-974 >98%
  • Packaging100mg
  • Price$1133.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181048
  • Product descriptionLGK-974 >98%
  • Packaging250mg
  • Price$2097.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181048
  • Product descriptionLGK-974 >98%
  • Packaging1000mg
  • Price$3432.3
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFL76327
  • Product descriptionLGK 974
  • Packaging50mg
  • Price$473
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFL76327
  • Product descriptionLGK 974
  • Packaging10mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14072
  • Product descriptionLGK974 ≥98%
  • Packaging500μg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14072
  • Product descriptionLGK974 ≥98%
  • Packaging1mg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14072
  • Product descriptionLGK974 ≥98%
  • Packaging5mg
  • Price$195
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2807
  • Product descriptionLGK974 99.74%
  • Packaging10mg
  • Price$204
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2807
  • Product descriptionLGK974 99.74%
  • Packaging50mg
  • Price$720
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2807
  • Product descriptionLGK974 99.74%
  • Packaging100mg
  • Price$1128
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2140AH 2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide 1g $4090 2021-12-16 Buy
ApexBio Technology B2307 LGK-974 5mg $110 2021-12-16 Buy
ApexBio Technology B2307 LGK-974 10mM(in 1mL DMSO) $140 2021-12-16 Buy
ApexBio Technology B2307 LGK-974 50mg $640 2021-12-16 Buy
Arctom CFN60103 LGK-974(WNT974) ≥98% 10mg $358 2021-12-16 Buy
Biorbyt Ltd orb181048 LGK-974 >98% 100mg $1133.9 2021-12-16 Buy
Biorbyt Ltd orb181048 LGK-974 >98% 250mg $2097.8 2021-12-16 Buy
Biorbyt Ltd orb181048 LGK-974 >98% 1000mg $3432.3 2021-12-16 Buy
Biosynth Carbosynth FL76327 LGK 974 50mg $473 2021-12-16 Buy
Biosynth Carbosynth FL76327 LGK 974 10mg $135 2021-12-16 Buy
Cayman Chemical 14072 LGK974 ≥98% 500μg $37 2024-03-01 Buy
Cayman Chemical 14072 LGK974 ≥98% 1mg $68 2024-03-01 Buy
Cayman Chemical 14072 LGK974 ≥98% 5mg $195 2024-03-01 Buy
ChemScene CS-2807 LGK974 99.74% 10mg $204 2021-12-16 Buy
ChemScene CS-2807 LGK974 99.74% 50mg $720 2021-12-16 Buy
ChemScene CS-2807 LGK974 99.74% 100mg $1128 2021-12-16 Buy

Properties

Melting point :176 - 180°C
Boiling point :650.9±55.0 °C(Predicted)
Density :1.268±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :12.24±0.70(Predicted)
form :Solid
color :White to Off-White

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. LGK974 is a potent and specific small molecule inhibitor of PORCN (IC50 = 0.4 nM). It greatly reduces Wnt secretion without decreasing its synthesis and without increasing cytotoxicity. LGK974 is orally bioavailable in mice and induces tumor regression in mouse breast tumors produced by mammary tumor virus-driven Wnt1 signaling. It also blocks carcinogenesis in other Wnt-related tumors at doses that have limited impact on stem cell renewal.

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