Wnt-C59
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- $44 - $2691.1
- Product name: Wnt-C59
- CAS: 1243243-89-1
- MF: C25H21N3O
- MW: 379.45
- EINECS:-0
- MDL Number:MFCD22201167
- Synonyms:Wnt-C59;2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetaMide;C59;Wnt-C59 (C59);4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide;4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide Wnt-c59;Wnt-C59, >=98%;WNT-C59 (C59);WNT C59;C59
31 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 50
- 10mM(in 1mL DMSO)
- 250mg
- 1g
- 1000mg
- ManufacturerAK Scientific
- Product number2142AH
- Product description2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide
- Packaging10mg
- Price$193
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8685
- Product descriptionWnt-C59
- Packaging5mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8685
- Product descriptionWnt-C59
- Packaging10mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8685
- Product descriptionWnt-C59
- Packaging10mM(in 1mL DMSO)
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8685
- Product descriptionWnt-C59
- Packaging50mg
- Price$590
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60102
- Product descriptionWnt-C59 ≥98%
- Packaging5mg
- Price$178
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2287
- Product descriptionWnt-C59-C59 98%
- Packaging5mg
- Price$115.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181132
- Product descriptionWnt-C59 >98%
- Packaging100mg
- Price$690.2
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181132
- Product descriptionWnt-C59 >98%
- Packaging250mg
- Price$1356.6
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181132
- Product descriptionWnt-C59 >98%
- Packaging1000mg
- Price$2691.1
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFM161562
- Product descriptionWnt-C59
- Packaging10mg
- Price$145
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFM161562
- Product descriptionWnt-C59
- Packaging50mg
- Price$645
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16644
- Product descriptionWnt-C59 ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16644
- Product descriptionWnt-C59 ≥98%
- Packaging5mg
- Price$109
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16644
- Product descriptionWnt-C59 ≥98%
- Packaging10mg
- Price$172
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16644
- Product descriptionWnt-C59 ≥98%
- Packaging50mg
- Price$723
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2142AH | 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide | 10mg | $193 | 2021-12-16 | Buy |
| ApexBio Technology | A8685 | Wnt-C59 | 5mg | $85 | 2021-12-16 | Buy |
| ApexBio Technology | A8685 | Wnt-C59 | 10mg | $140 | 2021-12-16 | Buy |
| ApexBio Technology | A8685 | Wnt-C59 | 10mM(in 1mL DMSO) | $180 | 2021-12-16 | Buy |
| ApexBio Technology | A8685 | Wnt-C59 | 50mg | $590 | 2021-12-16 | Buy |
| Arctom | CFN60102 | Wnt-C59 ≥98% | 5mg | $178 | 2021-12-16 | Buy |
| Axon Medchem | Axon2287 | Wnt-C59-C59 98% | 5mg | $115.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181132 | Wnt-C59 >98% | 100mg | $690.2 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181132 | Wnt-C59 >98% | 250mg | $1356.6 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181132 | Wnt-C59 >98% | 1000mg | $2691.1 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FM161562 | Wnt-C59 | 10mg | $145 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FM161562 | Wnt-C59 | 50mg | $645 | 2021-12-16 | Buy |
| Cayman Chemical | 16644 | Wnt-C59 ≥98% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 16644 | Wnt-C59 ≥98% | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 16644 | Wnt-C59 ≥98% | 10mg | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 16644 | Wnt-C59 ≥98% | 50mg | $723 | 2024-03-01 | Buy |
Properties
Melting point :>159°C (dec.)
Boiling point :628.3±55.0 °C(Predicted)
Density :1.198±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL)
form :Off-white powder
pka :13.78±0.70(Predicted)
color :Tan
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Boiling point :628.3±55.0 °C(Predicted)
Density :1.198±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL)
form :Off-white powder
pka :13.78±0.70(Predicted)
color :Tan
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety Information
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Description
Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. Wnt-C59 is a potent inhibitor of PORCN, as measured by prevention of Wnt3A activation (IC50 = 74 pM). As palmitoylation of Wnt is required for its secretion, Wnt-C59 completely blocks Wnt3A secretion into culture media. Wnt-C59 prevents activation of all evaluated Wnt family members. This compound is effective in vivo as well as in vitro. Whether given by intravenous (2.5 mg/kg) or oral administration (5 mg/kg), Wnt-C59 displays a half-life in blood of approximately 1.94 hours, and remains greater than 10-fold above the in vitro IC50 concentration for at least 16 hours after a single oral dose. It blocks the progression of both basal-like and triple-negative breast cancers while downregulating Wnt/β-catenin pathway target genes in mice.More related product prices
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