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ChemicalBook >> CAS DataBase List >> HMN-214

HMN-214

HMN-214 price.
  • $5 - $826
  • Product name: HMN-214
  • CAS: 173529-46-9
  • MF: C22H20N2O5S
  • MW: 424.47
  • EINECS:
  • MDL Number:MFCD12756255
  • Synonyms:HMN-214;(E)-4-[2-[2-[N-Acetyl-N-[(4-methoxyphenyl)sulfonyl]amino]phenyl]ethenyl]pyridine 1-oxide;HMN-214;HMN214;HMN 214;Acetamide, N-[(4-methoxyphenyl)sulfonyl]-N-[2-[(1E)-2-(1-oxido-4-pyridinyl)ethenyl]phenyl]-;(E)-4-[2-[2-[N-Acetyl-N-[(4-methoxyphenyl)sulfonyl]amino]phenyl]ethenyl]pyridine 1-oxide HMN 214;(E)-4-(2-(N-((4-methoxyphenyl)sulfonyl)acetamido)styryl)pyridine 1-oxide;HMN-214;HMN214;HMN 214;IVX214;CS-25
22 prices
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Brand
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 250mg
  • 1g
  • 100mg
  • 10mM(in 1mL DMSO)
  • ManufacturerAmbeed
  • Product numberA136004
  • Product descriptionHMN-214 98+%
  • Packaging25mg
  • Price$99
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0005218
  • Product descriptionHMN-214 95.00%
  • Packaging5MG
  • Price$330
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5413
  • Product descriptionHMN-214
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5413
  • Product descriptionHMN-214
  • Packaging10mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5413
  • Product descriptionHMN-214
  • Packaging10mM(in 1mL DMSO)
  • Price$176
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5413
  • Product descriptionHMN-214
  • Packaging50mg
  • Price$580
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS011510
  • Product descriptionHMN-214 ≥98%
  • Packaging100mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS011510
  • Product descriptionHMN-214 ≥98%
  • Packaging250mg
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS011510
  • Product descriptionHMN-214 ≥98%
  • Packaging1g
  • Price$23
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number26210
  • Product descriptionHMN-214
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number26210
  • Product descriptionHMN-214
  • Packaging5mg
  • Price$93
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number26210
  • Product descriptionHMN-214
  • Packaging10mg
  • Price$169
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number26210
  • Product descriptionHMN-214
  • Packaging25mg
  • Price$365
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM176458
  • Product description(E)-4-[2-[2-[N-Acetyl-N-[(4-methoxyphenyl)sulfonyl]amino]phenyl]ethenyl]pyridine1-oxide 98%
  • Packaging100mg
  • Price$826
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0202
  • Product descriptionHMN-214 99.65%
  • Packaging10mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0202
  • Product descriptionHMN-214 99.65%
  • Packaging50mg
  • Price$450
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A136004 HMN-214 98+% 25mg $99 2021-12-16 Buy
American Custom Chemicals Corporation API0005218 HMN-214 95.00% 5MG $330 2021-12-16 Buy
ApexBio Technology A5413 HMN-214 5mg $120 2021-12-16 Buy
ApexBio Technology A5413 HMN-214 10mg $160 2021-12-16 Buy
ApexBio Technology A5413 HMN-214 10mM(in 1mL DMSO) $176 2021-12-16 Buy
ApexBio Technology A5413 HMN-214 50mg $580 2021-12-16 Buy
Arctom AS011510 HMN-214 ≥98% 100mg $5 2021-12-16 Buy
Arctom AS011510 HMN-214 ≥98% 250mg $9 2021-12-16 Buy
Arctom AS011510 HMN-214 ≥98% 1g $23 2021-12-16 Buy
Cayman Chemical 26210 HMN-214 1mg $32 2024-03-01 Buy
Cayman Chemical 26210 HMN-214 5mg $93 2024-03-01 Buy
Cayman Chemical 26210 HMN-214 10mg $169 2024-03-01 Buy
Cayman Chemical 26210 HMN-214 25mg $365 2024-03-01 Buy
Chemenu CM176458 (E)-4-[2-[2-[N-Acetyl-N-[(4-methoxyphenyl)sulfonyl]amino]phenyl]ethenyl]pyridine1-oxide 98% 100mg $826 2021-12-16 Buy
ChemScene CS-0202 HMN-214 99.65% 10mg $150 2021-12-16 Buy
ChemScene CS-0202 HMN-214 99.65% 50mg $450 2021-12-16 Buy

Properties

Boiling point :663.1±65.0 °C(Predicted)
Density :1.24
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :≥21.2 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :0.86±0.10(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

HMN-214 is an orally bioavailable prodrug form of HMN-176, an indirect inhibitor of polo-like kinase (PLK) activity that inhibits proliferation of a variety of cancer cells. HMN-214 decreases the expression of multidrug resistance gene 1 (MDR1) in AB-A.1 cells and in tumors isolated from mice bearing multidrug-resistant KB-A1 xenografts. HMN-214 (20 mg/kg per day) reduces tumor volume in PC3, WiDr, and A549 mouse xenograft models. It does not decrease nerve conduction velocity or compound action potential amplitude in rabbit sciatic nerves in vivo when administered at a concentration of 30 mg/kg per day.