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ChemicalBook >> CAS DataBase List >> N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine

N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine

N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine price.
  • $28 - $6480
  • Product name: N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine
  • CAS: 881202-45-5
  • MF: C21H20N4
  • MW: 328.41
  • EINECS:200-256-5
  • MDL Number:MFCD16620518
  • Synonyms:N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine;JNJ 26854165;SerdeMetan;JNJ-26854165 (SerdeMetan);JNJ 26854165 N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine;N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine JNJ 26854165;JNJ-26854165, >=98%;N1-[2-(1H-indol-3-yl)ethyl]-N4-4-pyridinyl-1,4-Benzene diamine
34 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • TRC
Package
  • 1mg
  • 10mM(in 1mL DMSO)
  • 1unit
  • 5MG
  • 2x5mg
  • 10MG
  • 25MG
  • 50MG
  • 100mg
  • 250mg
  • 1g
  • 1000mg
  • ManufacturerAK Scientific
  • Product numberX7539
  • Product descriptionSerdemetan
  • Packaging1g
  • Price$2273
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000886
  • Product descriptionJNJ-26854165 95.00%
  • Packaging5MG
  • Price$462
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000886
  • Product descriptionJNJ-26854165 95.00%
  • Packaging10MG
  • Price$494
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000886
  • Product descriptionJNJ-26854165 95.00%
  • Packaging25MG
  • Price$580
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000886
  • Product descriptionJNJ-26854165 95.00%
  • Packaging50MG
  • Price$727
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000886
  • Product descriptionJNJ-26854165 95.00%
  • Packaging1G
  • Price$6480
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4204
  • Product descriptionJNJ-26854165(Serdemetan)
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4204
  • Product descriptionJNJ-26854165(Serdemetan)
  • Packaging5mg
  • Price$64
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4204
  • Product descriptionJNJ-26854165(Serdemetan)
  • Packaging10mM(in 1mL DMSO)
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4204
  • Product descriptionJNJ-26854165(Serdemetan)
  • Packaging25mg
  • Price$224
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4204
  • Product descriptionJNJ-26854165(Serdemetan)
  • Packaging100mg
  • Price$632
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1538
  • Product descriptionJNJ26854165-Serdemetan 99%
  • Packaging2x5mg
  • Price$176
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181039
  • Product descriptionJNJ-26854165 (Serdemetan) >98%
  • Packaging100mg
  • Price$690.2
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181039
  • Product descriptionJNJ-26854165 (Serdemetan) >98%
  • Packaging250mg
  • Price$1356.6
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181039
  • Product descriptionJNJ-26854165 (Serdemetan) >98%
  • Packaging1000mg
  • Price$2691.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFI151818
  • Product descriptionJNJ 26854165
  • Packaging10mg
  • Price$95
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7539 Serdemetan 1g $2273 2021-12-16 Buy
American Custom Chemicals Corporation INB0000886 JNJ-26854165 95.00% 5MG $462 2021-12-16 Buy
American Custom Chemicals Corporation INB0000886 JNJ-26854165 95.00% 10MG $494 2021-12-16 Buy
American Custom Chemicals Corporation INB0000886 JNJ-26854165 95.00% 25MG $580 2021-12-16 Buy
American Custom Chemicals Corporation INB0000886 JNJ-26854165 95.00% 50MG $727 2021-12-16 Buy
American Custom Chemicals Corporation INB0000886 JNJ-26854165 95.00% 1G $6480 2021-12-16 Buy
ApexBio Technology A4204 JNJ-26854165(Serdemetan) 1unit $28 2021-12-16 Buy
ApexBio Technology A4204 JNJ-26854165(Serdemetan) 5mg $64 2021-12-16 Buy
ApexBio Technology A4204 JNJ-26854165(Serdemetan) 10mM(in 1mL DMSO) $100 2021-12-16 Buy
ApexBio Technology A4204 JNJ-26854165(Serdemetan) 25mg $224 2021-12-16 Buy
ApexBio Technology A4204 JNJ-26854165(Serdemetan) 100mg $632 2021-12-16 Buy
Axon Medchem Axon1538 JNJ26854165-Serdemetan 99% 2x5mg $176 2021-12-16 Buy
Biorbyt Ltd orb181039 JNJ-26854165 (Serdemetan) >98% 100mg $690.2 2021-12-16 Buy
Biorbyt Ltd orb181039 JNJ-26854165 (Serdemetan) >98% 250mg $1356.6 2021-12-16 Buy
Biorbyt Ltd orb181039 JNJ-26854165 (Serdemetan) >98% 1000mg $2691.1 2021-12-16 Buy
Biosynth Carbosynth FI151818 JNJ 26854165 10mg $95 2021-12-16 Buy

Properties

storage temp. :Store at -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥14.8 mg/mL in DMSO
form :solid
color :Light brown to brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The E3 ubiquitin ligase known as murine double minute 2 (MDM2; HDM2 in humans) binds to and then ubiquitinates several proteins, most notably the tumor suppressor p53. JNJ-26854165 is an antagonist of MDM2 that suppresses the growth of cancer cell lines expressing wild-type p53 (IC50 values range from 240-440 nM). It induces p53-mediated transcription culminating in apoptotic death of acute leukemia cells. JNJ-26854165 is orally bioavailable and has anti-proliferative as well as apoptotic actions in various tumor models. As MDM2 interacts with and modulates several targets in addition to p53, JNJ-26854165 affects multiple signaling pathways.

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