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ChemicalBook >> CAS DataBase List >> 5-Fluorocytosine

5-Fluorocytosine

5-Fluorocytosine price.
  • $5 - $1500
  • Product name: 5-Fluorocytosine
  • CAS: 2022-85-7
  • MF: C4H4FN3O
  • MW: 129.09
  • EINECS:217-968-7
  • MDL Number:MFCD00006035
  • Synonyms:4-amino-5-fluoro-2(1h)-pyrimidinon ;4-Amino-5-fluoro-2(1H)-pyrmidinone ;5-fluorocystosine ;5-fluoro-cytosin ;fluocytosine ;4-Amino-5-Fluoro-2(1H)-pyrimidine, Flucytosine, 5-FC;5-Fluorocytosine98%;5-FLUOROCYTOSINE(FLUCYTOSINE)
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  • Adipogen Life Sciences
  • AHH
  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Crysdot
  • CSNpharm
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  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • SynQuest Laboratories
  • TCI Chemical
  • TRC
  • Usbiological
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  • f0175000
  • 5MG
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  • 5g
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  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-F0077-G001
  • Product description5-Fluorocytosine ≥99%(TLC)
  • Packaging1g
  • Price$141
  • Updated2021-12-16
  • Buy
  • ManufacturerAHH
  • Product numberMT-13095
  • Product description5-Fluorocytosine 98%
  • Packaging100g
  • Price$345
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberE353
  • Product description5-Fluorocytosine
  • Packaging4x25g
  • Price$67
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberL16496
  • Product description5-Fluorocytosine, 98+%
  • Packaging250mg
  • Price$35.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberL16496
  • Product description5-Fluorocytosine, 98+%
  • Packaging1g
  • Price$86.7
  • Updated2024-03-01
  • Buy
  • ManufacturerAmbeed
  • Product numberA200898
  • Product description5-Fluorocytosine 97+%
  • Packaging5g
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200898
  • Product description5-Fluorocytosine 97+%
  • Packaging10g
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200898
  • Product description5-Fluorocytosine 97+%
  • Packaging25g
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200898
  • Product description5-Fluorocytosine 97+%
  • Packaging100g
  • Price$36
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200898
  • Product description5-Fluorocytosine 97+%
  • Packaging500g
  • Price$139
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA200898
  • Product description5-Fluorocytosine 97+%
  • Packaging1kg
  • Price$214
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberHCH0029105
  • Product description6-AMINO-5-FLUORO-2(1H)-PYRIMIDINONE 95.00%
  • Packaging5MG
  • Price$500.01
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8433
  • Product descriptionFlucytosine
  • Packaging1g
  • Price$47
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8433
  • Product descriptionFlucytosine
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8433
  • Product descriptionFlucytosine
  • Packaging5g
  • Price$98
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberPC3735
  • Product description5-Fluorocytosine 98%
  • Packaging25g
  • Price$10
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences CDX-F0077-G001 5-Fluorocytosine ≥99%(TLC) 1g $141 2021-12-16 Buy
AHH MT-13095 5-Fluorocytosine 98% 100g $345 2021-12-16 Buy
AK Scientific E353 5-Fluorocytosine 4x25g $67 2021-12-16 Buy
Alfa Aesar L16496 5-Fluorocytosine, 98+% 250mg $35.65 2024-03-01 Buy
Alfa Aesar L16496 5-Fluorocytosine, 98+% 1g $86.7 2024-03-01 Buy
Ambeed A200898 5-Fluorocytosine 97+% 5g $5 2021-12-16 Buy
Ambeed A200898 5-Fluorocytosine 97+% 10g $7 2021-12-16 Buy
Ambeed A200898 5-Fluorocytosine 97+% 25g $10 2021-12-16 Buy
Ambeed A200898 5-Fluorocytosine 97+% 100g $36 2021-12-16 Buy
Ambeed A200898 5-Fluorocytosine 97+% 500g $139 2021-12-16 Buy
Ambeed A200898 5-Fluorocytosine 97+% 1kg $214 2021-12-16 Buy
American Custom Chemicals Corporation HCH0029105 6-AMINO-5-FLUORO-2(1H)-PYRIMIDINONE 95.00% 5MG $500.01 2021-12-16 Buy
ApexBio Technology A8433 Flucytosine 1g $47 2021-12-16 Buy
ApexBio Technology A8433 Flucytosine 10mM(in 1mL DMSO) $55 2021-12-16 Buy
ApexBio Technology A8433 Flucytosine 5g $98 2021-12-16 Buy
Apolloscientific PC3735 5-Fluorocytosine 98% 25g $10 2021-12-16 Buy

Properties

Melting point :298-300 °C (dec.) (lit.)
Density :1.3990 (estimate)
vapor pressure :0Pa at 25℃
storage temp. :2-8°C
solubility :Sparingly soluble in water, slightly soluble in ethanol (96 per cent)
form :Crystalline Powder
pka :3.26(at 25℃)
color :White to almost white
Water Solubility :1.5g/100mL (25 ºC)
Sensitive :Light Sensitive
Merck :14,4125
BRN :127285
BCS Class :1
Stability :Light Sensitive
InChIKey :XRECTZIEBJDKEO-UHFFFAOYSA-N
LogP :-1.36 at 22.1℃ and pH6.4-6.9
Dissociation constant :2.74-10.71 at 21.4℃
CAS DataBase Reference :2022-85-7(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

5-Fluorocytosine (5-FC), a fluorinated pyrimidine analog, is a synthetic antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil. 5-fluorouracil, a widely used cytotoxic drug, is further metabolized to fluorinated ribo- and deoxyribonucleotides, resulting in the inhibition of DNA and protein synthesis, which has multiple effects including inhibition of Candida species and C. neoformans infections and cytotoxicity towards cancer cells. In combination with a retroviral replicating vector carrying a cytosine deaminase prodrug-activating gene, 5-FC has been shown to selectively eliminate CT26 and Tu-2449 tumor cells in vitro (IC50s = 4.2 and 1.5 μM, respectively) and to significantly improve survival and reduce tumor size (at a dose of 500 mg/kg) in two different syngeneic mouse glioma models.

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