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ChemicalBook >> CAS DataBase List >> Dolasetron mesylate

Dolasetron mesylate

Dolasetron mesylate price.
  • $40 - $1273.39
  • Product name: Dolasetron mesylate
  • CAS: 115956-13-3
  • MF: C20H26N2O7S
  • MW: 438.49
  • EINECS:601-404-5
  • MDL Number:MFCD01718979
  • Synonyms:DOLASETRON MESYLATE:DOLASETRON;Dolasetron mesylate/(2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate monomethanesulfonate;(2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate monomethanesulfonate;Dolasetron Mesylate (200 mg);Dolasetron Mesylate hydrate;Dalasetron (Mesylate);Anzemet hydrate;Dolasetron methanesulfonate hydrate
13 prices
Selected condition:
Brand
  • AHH
  • AK Scientific
  • American Custom Chemicals Corporation
  • Biosynth Carbosynth
  • Crysdot
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 5G
  • ManufacturerAHH
  • Product numberAPI-1725
  • Product descriptionDolasetron mesylate 98%
  • Packaging1g
  • Price$840
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ55837
  • Product descriptionDolasetron Mesylate Monohydrate
  • Packaging50mg
  • Price$187
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ55837
  • Product descriptionDolasetron Mesylate Monohydrate
  • Packaging10mg
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002473
  • Product descriptionDOLASETRON MESYLATE 95.00%
  • Packaging5G
  • Price$1273.39
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002473
  • Product descriptionDOLASETRON MESYLATE 95.00%
  • Packaging10MG
  • Price$255.15
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD14809
  • Product descriptionDolasetron mesylate
  • Packaging25mg
  • Price$58
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD14809
  • Product descriptionDolasetron mesylate
  • Packaging100mg
  • Price$173
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11344624
  • Product descriptionDolasetron mesylate 97%
  • Packaging50mg
  • Price$151
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11344624
  • Product descriptionDolasetron mesylate 97%
  • Packaging10mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number17450
  • Product descriptionDolasetron mesylate >98%
  • Packaging10mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberD9571
  • Product descriptionDolasetron mesylate hydrate ≥98% (HPLC), powder
  • Packaging10mg
  • Price$92.7
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberD9571
  • Product descriptionDolasetron mesylate hydrate ≥98% (HPLC), powder
  • Packaging50mg
  • Price$301
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberD528505
  • Product descriptionDolasetron mesylate
  • Packaging250mg
  • Price$990
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH API-1725 Dolasetron mesylate 98% 1g $840 2021-12-16 Buy
AK Scientific J55837 Dolasetron Mesylate Monohydrate 50mg $187 2021-12-16 Buy
AK Scientific J55837 Dolasetron Mesylate Monohydrate 10mg $49 2021-12-16 Buy
American Custom Chemicals Corporation API0002473 DOLASETRON MESYLATE 95.00% 5G $1273.39 2021-12-16 Buy
American Custom Chemicals Corporation API0002473 DOLASETRON MESYLATE 95.00% 10MG $255.15 2021-12-16 Buy
Biosynth Carbosynth FD14809 Dolasetron mesylate 25mg $58 2021-12-16 Buy
Biosynth Carbosynth FD14809 Dolasetron mesylate 100mg $173 2021-12-16 Buy
Crysdot CD11344624 Dolasetron mesylate 97% 50mg $151 2021-12-16 Buy
Crysdot CD11344624 Dolasetron mesylate 97% 10mg $40 2021-12-16 Buy
Medical Isotopes, Inc. 17450 Dolasetron mesylate >98% 10mg $200 2021-12-16 Buy
Sigma-Aldrich D9571 Dolasetron mesylate hydrate ≥98% (HPLC), powder 10mg $92.7 2024-03-01 Buy
Sigma-Aldrich D9571 Dolasetron mesylate hydrate ≥98% (HPLC), powder 50mg $301 2024-03-01 Buy
TRC D528505 Dolasetron mesylate 250mg $990 2021-12-16 Buy

Properties

Melting point :278°
storage temp. :Sealed in dry,2-8°C
solubility :H2O: >30mg/mL
form :powder
color :white to off-white
CAS DataBase Reference :115956-13-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Dolasetron was launched as Anzemet in Australia and the US for the prevention of nausea and vomiting in chemotherapy patients. It is a highly potent and very selective antagonist of 5-HT3 receptors ; it is the sixth in this class of compounds to be marketed for the treatment of chemotherapy-induced emesis. The last two approved in this class were Nazasetron (1994) and Ramosetron (1996). Anzemet was prepared by a seven step sequence from a cyclopentenecarboxylic ester via a Robinson-Schopf cyclisation of a dialdehyde into a key 9-azabicyclo[3.3.l]nonan-3-one. In a clinical study with 164 cancer patients treated with Dolasetron mesylate prior to Cisplatin, single doses of 10- 50 mg achieved major control of nausea and emesis in 73% of subjects and were well tolerated. Results from pharmacokinetic studies in humans showed that the clinical effects and duration of action seem to be due mainly to a major plasma metabolite rapidly formed and very potent itself, the (+) enantiomeric alcohol obtained by enzymatic reduction of the cyclic ketone.