Cladribine
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- $22 - $1504.5
- Product name: Cladribine
- CAS: 4291-63-8
- MF: C10H12ClN5O3
- MW: 285.69
- EINECS:636-978-6
- MDL Number:MFCD00153939
- Synonyms:2-chlorodeoxyadenosine ;Biodribin;Cladarabine;Jk 6251;NSC 105014;(2R,3S,5R)-5-(6-aMino-2-chloro-9H-purin-9-yl)-2-(hydroxyMethyl)oxolan-3-ol;Cladribine API;2-Chloro-2'-deoxyadenosine 2-Chloro-9-(2-deoxy-beta-D-arabinofuranosyl)adenine CdA
63 prices
Selected condition：
Brand
- AHH
- AK Scientific
- Ambeed
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth Carbosynth
- BroadPharm
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 10
- 10mg
- 10μg
- y0000609
- 100mg
- 200mg
- 500mg
- 50
- 25mg
- 50mg
- 250mg
- 1g
- 5g
- 48Tests
- y0000639
- ManufacturerAHH
- Product numberMT-49426
- Product descriptionCladribine 98%
- Packaging1g
- Price$430
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberE997
- Product descriptionCladribine
- Packaging50mg
- Price$469
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA410468
- Product description(2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+%
- Packaging5g
- Price$672
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA410468
- Product description(2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+%
- Packaging1g
- Price$187
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA410468
- Product description(2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+%
- Packaging250mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA410468
- Product description(2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+%
- Packaging100mg
- Price$43
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA410468
- Product description(2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+%
- Packaging50mg
- Price$33
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA410468
- Product description(2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+%
- Packaging10mg
- Price$25
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2187
- Product descriptionCladribine
- Packaging100mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIMN2008
- Product description2-Chloro-2?-deoxyadenosine
- Packaging100mg
- Price$109
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIMN2008
- Product description2-Chloro-2?-deoxyadenosine
- Packaging250mg
- Price$240
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIMN2008
- Product description2-Chloro-2?-deoxyadenosine
- Packaging1g
- Price$617
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS003462
- Product description(2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol ≥98%
- Packaging10mg
- Price$25
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS003462
- Product description(2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol ≥98%
- Packaging50mg
- Price$33
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS003462
- Product description(2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol ≥98%
- Packaging100mg
- Price$43
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS003462
- Product description(2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol ≥98%
- Packaging250mg
- Price$74
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AHH | MT-49426 | Cladribine 98% | 1g | $430 | 2021-12-16 | Buy |
| AK Scientific | E997 | Cladribine | 50mg | $469 | 2021-12-16 | Buy |
| Ambeed | A410468 | (2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+% | 5g | $672 | 2021-12-16 | Buy |
| Ambeed | A410468 | (2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+% | 1g | $187 | 2021-12-16 | Buy |
| Ambeed | A410468 | (2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+% | 250mg | $75 | 2021-12-16 | Buy |
| Ambeed | A410468 | (2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+% | 100mg | $43 | 2021-12-16 | Buy |
| Ambeed | A410468 | (2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+% | 50mg | $33 | 2021-12-16 | Buy |
| Ambeed | A410468 | (2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 98+% | 10mg | $25 | 2021-12-16 | Buy |
| ApexBio Technology | A2187 | Cladribine | 100mg | $150 | 2021-12-16 | Buy |
| Apolloscientific | BIMN2008 | 2-Chloro-2?-deoxyadenosine | 100mg | $109 | 2021-12-16 | Buy |
| Apolloscientific | BIMN2008 | 2-Chloro-2?-deoxyadenosine | 250mg | $240 | 2021-12-16 | Buy |
| Apolloscientific | BIMN2008 | 2-Chloro-2?-deoxyadenosine | 1g | $617 | 2021-12-16 | Buy |
| Arctom | AS003462 | (2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol ≥98% | 10mg | $25 | 2021-12-16 | Buy |
| Arctom | AS003462 | (2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol ≥98% | 50mg | $33 | 2021-12-16 | Buy |
| Arctom | AS003462 | (2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol ≥98% | 100mg | $43 | 2021-12-16 | Buy |
| Arctom | AS003462 | (2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol ≥98% | 250mg | $74 | 2021-12-16 | Buy |
Properties
Melting point :181-185 °C(lit.)
alpha :D25 -18.8° (c = 1 in DMF)
Boiling point :547.6±60.0 °C(Predicted)
Density :2.03±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Slightly soluble in water, soluble in dimethyl sulfoxide, slightly soluble in methanol, practically insoluble in acetonitrile. It shows polymorphism (5.9).
pka :13.75±0.60(Predicted)
form :White solid
color :White to Pale Yellow
λmax :265nm(EtOH aq.)(lit.)
Merck :14,2337
Stability :Store in Freezer
InChIKey :PTOAARAWEBMLNO-HSUXUTPPSA-N
CAS DataBase Reference :4291-63-8(CAS DataBase Reference)
alpha :D25 -18.8° (c = 1 in DMF)
Boiling point :547.6±60.0 °C(Predicted)
Density :2.03±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Slightly soluble in water, soluble in dimethyl sulfoxide, slightly soluble in methanol, practically insoluble in acetonitrile. It shows polymorphism (5.9).
pka :13.75±0.60(Predicted)
form :White solid
color :White to Pale Yellow
λmax :265nm(EtOH aq.)(lit.)
Merck :14,2337
Stability :Store in Freezer
InChIKey :PTOAARAWEBMLNO-HSUXUTPPSA-N
CAS DataBase Reference :4291-63-8(CAS DataBase Reference)
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | ||||||||||||||||||||||||||||
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Description
Cladribine (2-chloro-2′-deoxyadenosine) is an adenosine deaminase-resistant analogue of deoxyadenosine. The drug has a broad range of in vitro activity against both lymphoid and myeloid neoplasms [mean IC50values (drug concentration required to inhibit cell growth by 50% of control): 20 to 87 nmol/L]. But it possesses little activity against multiple myeloma specimens and many solid tumor cell lines. Monocytes are highly sensitive to cladribine in vitro. Cladribine demonstrates activity against both dividing and nondividing cells and this activity distinguishes it from many other agents. It has activity in murine models of leukaemia. Cladribine is used to treat chronic progressive multiple sclerosis, hairy cell leukemia, systemic mastocytosis, and histiocytosis (including Erdheim–Chester disease and Langerhans cell histiocytosis).After a 2-hour intravenous infusion of cladribine 0.14 mg/kg/day, the mean maximum plasma drug concentration was 198 nmol/L. Intracellular concentrations of phosphorylated cladribine derivatives exceed plasma concentrations 128- to 375-fold. Cladribine penetrates into the CSF. The terminal elimination half-life (6.7 hours) is long, which suggests that the drug may be administered intermittently without loss of efficacy. The volume of distribution of cladribine is 9.2 L/kg.
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Suppliers and manufacturers
Capot Chemical Co.,Ltd.
Henan Tianfu Chemical Co.,Ltd.
Hangzhou FandaChem Co.,Ltd.
Hainan Xiyuan Chemical Technology Co., Ltd.
