REVIEW Cladribine (trade names Litak and Movectro) is a purine nucleoside used to treat hairy cell leukemia (HCL, leukemic reticuloendotheliosis) and multiple sclerosis. It mimics the nucleoside adenosine and inhibiting the enzyme adenosine deaminase, which interferes with the cell''s ability to process DNA. It is easily destroyed by normal cells except for blood cells, with the result that it produces relatively few side effects and results in very little non-target cell loss.
REFERENCES
[1]
Morris, Ashley K.; Kolesar, Jill M.; Kuhn, John G, Purine nucleoside analogs: fludarabine, pentostatin, and cladribine. Part 3: cladribine, Journal of Oncology Pharmacy Practice (1997), 3(2), 94-109.
[2]
Juliusson, Gunnar; Liliemark, Jan; Mechanisms of action, pharmacokinetics, and routes of administration of 2-chlorodeoxyadenosine in hairy cell leukemia, Advances in Blood Disorders (2000), 5(Hairy Cell Leukemia), 163-170.
[3]
Tallman, Martin S.; Hakimian, David; Hoffman, Mark A.; Rai, Kanti; Treatment of hairy cell leukemia with 2-chlorodeoxyadenosineAdvances in Blood Disorders (2000), 5(Hairy Cell Leukemia), 171-180.
[4]
Goodman, Grant R.; Beutler, Ernest; Saven, Alan; Cladribine in the treatment of hairy-cell leukaemiaBest Practice & Research, Clinical Haematology (2003), 16(1), 101-116.
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WARNING: Attention California residents: This product can expose you to chemicals including Cladribine, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.
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