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ChemicalBook >> CAS DataBase List >> 7-Ethyl-10-hydroxycamptothecin

7-Ethyl-10-hydroxycamptothecin

7-Ethyl-10-hydroxycamptothecin price.
  • $13 - $4420
  • Product name: 7-Ethyl-10-hydroxycamptothecin
  • CAS: 86639-52-3
  • MF: C22H20N2O5
  • MW: 392.4
  • EINECS:643-093-9
  • MDL Number:MFCD06762720
  • Synonyms:7-10-hydroxycamptothecin;(4S)-4,9-Dihydroxy-4,11-diethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(4S)-4,9-Dihydroxy-4α,11-diethyl-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione;EHCPT;7-Ethyl-10-hydroxy-CPT (Camptothecine), SN-38;10-Hydroxycamptothecin acetate salt ,99%;Irinotecan Related Compound B (10 mg) ((S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione);SN 38(7-Ethyl-10-hydroxycaMptothecin)
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  • Abosyn
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  • AK Scientific
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  • 10mM(in 1mL DMSO)
  • ManufacturerAbosyn
  • Product number61-3255
  • Product description(S)-4,11-diethyl-4,8-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 95+%
  • Packaging10g
  • Price$675
  • Updated2021-12-16
  • Buy
  • ManufacturerAbosyn
  • Product number61-3255
  • Product description(S)-4,11-diethyl-4,8-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 95+%
  • Packaging25g
  • Price$1305
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberAT5299
  • Product description7-ethyl-10-hydroxycamptothecin 99.00%
  • Packaging1G
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberAT5299
  • Product description7-ethyl-10-hydroxycamptothecin 99.00%
  • Packaging25G
  • Price$710
  • Updated2021-12-16
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  • ManufacturerAccelPharmtech
  • Product numberAT5299
  • Product description7-ethyl-10-hydroxycamptothecin 99.00%
  • Packaging100G
  • Price$2010
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberAT5299
  • Product description7-ethyl-10-hydroxycamptothecin 99.00%
  • Packaging250G
  • Price$4420
  • Updated2021-12-16
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  • ManufacturerAHH
  • Product numberAPI-1296
  • Product description7-Ethyl-10-hydroxycamptothecin 98%
  • Packaging1g
  • Price$610
  • Updated2021-12-16
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  • ManufacturerAK Scientific
  • Product numberJ90015
  • Product descriptionSN-38
  • Packaging1g
  • Price$74
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA366170
  • Product description(S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging100mg
  • Price$20
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA366170
  • Product description(S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging50mg
  • Price$20
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA366170
  • Product description(S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging250mg
  • Price$74
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA366170
  • Product description(S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging1g
  • Price$292
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA366170
  • Product description(S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging5g
  • Price$511
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA366170
  • Product description(S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging10g
  • Price$1092
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA366170
  • Product description(S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging25g
  • Price$1092
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberN2133
  • Product description7-Ethyl-10-hydroxycamptothecin
  • Packaging20mg
  • Price$35
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Abosyn 61-3255 (S)-4,11-diethyl-4,8-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 95+% 10g $675 2021-12-16 Buy
Abosyn 61-3255 (S)-4,11-diethyl-4,8-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 95+% 25g $1305 2021-12-16 Buy
AccelPharmtech AT5299 7-ethyl-10-hydroxycamptothecin 99.00% 1G $130 2021-12-16 Buy
AccelPharmtech AT5299 7-ethyl-10-hydroxycamptothecin 99.00% 25G $710 2021-12-16 Buy
AccelPharmtech AT5299 7-ethyl-10-hydroxycamptothecin 99.00% 100G $2010 2021-12-16 Buy
AccelPharmtech AT5299 7-ethyl-10-hydroxycamptothecin 99.00% 250G $4420 2021-12-16 Buy
AHH API-1296 7-Ethyl-10-hydroxycamptothecin 98% 1g $610 2021-12-16 Buy
AK Scientific J90015 SN-38 1g $74 2021-12-16 Buy
Ambeed A366170 (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 100mg $20 2021-12-16 Buy
Ambeed A366170 (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 50mg $20 2021-12-16 Buy
Ambeed A366170 (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 250mg $74 2021-12-16 Buy
Ambeed A366170 (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 1g $292 2021-12-16 Buy
Ambeed A366170 (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 5g $511 2021-12-16 Buy
Ambeed A366170 (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 10g $1092 2021-12-16 Buy
Ambeed A366170 (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 25g $1092 2021-12-16 Buy
ApexBio Technology N2133 7-Ethyl-10-hydroxycamptothecin 20mg $35 2021-12-16 Buy

Properties

Melting point :217 °C
Boiling point :810.3±65.0 °C(Predicted)
Density :1.51±0.1 g/cm3(Predicted)
refractive index :21.5 ° (C=0.2, THF)
storage temp. :2-8°C
solubility :DMSO: soluble1mg/mL
form :powder
pka :9.13±0.40(Predicted)
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI :InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
InChIKey :FJHBVJOVLFPMQE-QFIPXVFZSA-N
SMILES :N1C2C(=CC(O)=CC=2)C(CC)=C2CN3C(C=12)=CC1[C@](CC)(O)C(=O)OCC=1C3=O
CAS DataBase Reference :86639-52-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

SN-38 is the active metabolite of irinotecan , a derivative of the alkaloid camptothecin , and acts as a potent inhibitor of DNA topoisomerase I. It is formed by the hydrolysis of irinotecan by carboxylesterases and metabolized through glucuronidation by UDP glucuronosyl transferase 1A1. SN-38 is a more potent topopisomerase I inhibitor and more cytotoxic to HT-29 colon cancer cells (IC50 = 8.8 nM) compared to irinotecan (IC50 > 100 nM).

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