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ChemicalBook >> CAS DataBase List >> 17-AAG

17-AAG

17-AAG price.
  • $28 - $8100
  • Product name: 17-AAG
  • CAS: 75747-14-7
  • MF: C31H43N3O8
  • MW: 585.69
  • EINECS:
  • MDL Number:MFCD04973892
  • Synonyms:GELDANAMYCIN,17-DEMETHOXY-17-(2-PROPENYLAMINO)-;CP 127374;ALLYLAMINOGELDANAMYCIN;NSC-330507;17-(ALLYLAMINO)-17-DEMETHOXYGELDANAMYCIN;17-(ALLYLAMINO)-17-DESMETHOXYGELDANAMYCIN;17-(ALLYLAMINO)-17-DIMETHOXYGELDANAMYCIN;17-ALLYLAMINOGELDANAMYCIN
62 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • AHH
  • AK Scientific
  • Alfa Aesar
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Iris Biotech GmbH
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 500μg
  • 1
  • 1unit
  • 1mg
  • 0.001g
  • 5mg
  • 10mg
  • 20mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 1g
  • 10mM(in 1mL DMSO)
  • ManufacturerAdipogen Life Sciences
  • Product numberBVT-0244-M005
  • Product description17-AAG ≥98%(HPLC)
  • Packaging5mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerAHH
  • Product numberMT-27757
  • Product description17-Allylaminogeldanamycin 99%
  • Packaging0.001g
  • Price$230
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7553
  • Product descriptionTanespimycin
  • Packaging25mg
  • Price$186
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7553
  • Product descriptionTanespimycin
  • Packaging200mg
  • Price$462
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ66960
  • Product description17-(Allylamino)-17-demethoxygeldanamycin, 99%
  • Packaging25mg
  • Price$109.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ66960
  • Product description17-(Allylamino)-17-demethoxygeldanamycin, 99%
  • Packaging100mg
  • Price$258.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ66960
  • Product description17-(Allylamino)-17-demethoxygeldanamycin, 99%
  • Packaging200mg
  • Price$362.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAmbeed
  • Product numberA220462
  • Product description(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-ylcarbamate 98+%
  • Packaging5mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA220462
  • Product description(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-ylcarbamate 98+%
  • Packaging10mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA220462
  • Product description(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-ylcarbamate 98+%
  • Packaging25mg
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA220462
  • Product description(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-ylcarbamate 98+%
  • Packaging50mg
  • Price$311
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA220462
  • Product description(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-ylcarbamate 98+%
  • Packaging100mg
  • Price$404
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA220462
  • Product description(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-ylcarbamate 98+%
  • Packaging250mg
  • Price$808
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA220462
  • Product description(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-ylcarbamate 98+%
  • Packaging1g
  • Price$2503
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0009843
  • Product description17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN 95.00%
  • Packaging10MG
  • Price$650.27
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0009843
  • Product description17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN 95.00%
  • Packaging50MG
  • Price$752.14
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences BVT-0244-M005 17-AAG ≥98%(HPLC) 5mg $75 2021-12-16 Buy
AHH MT-27757 17-Allylaminogeldanamycin 99% 0.001g $230 2021-12-16 Buy
AK Scientific X7553 Tanespimycin 25mg $186 2021-12-16 Buy
AK Scientific X7553 Tanespimycin 200mg $462 2021-12-16 Buy
Alfa Aesar J66960 17-(Allylamino)-17-demethoxygeldanamycin, 99% 25mg $109.65 2024-03-01 Buy
Alfa Aesar J66960 17-(Allylamino)-17-demethoxygeldanamycin, 99% 100mg $258.65 2024-03-01 Buy
Alfa Aesar J66960 17-(Allylamino)-17-demethoxygeldanamycin, 99% 200mg $362.65 2024-03-01 Buy
Ambeed A220462 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-ylcarbamate 98+% 5mg $95 2021-12-16 Buy
Ambeed A220462 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-ylcarbamate 98+% 10mg $120 2021-12-16 Buy
Ambeed A220462 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-ylcarbamate 98+% 25mg $240 2021-12-16 Buy
Ambeed A220462 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-ylcarbamate 98+% 50mg $311 2021-12-16 Buy
Ambeed A220462 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-ylcarbamate 98+% 100mg $404 2021-12-16 Buy
Ambeed A220462 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-ylcarbamate 98+% 250mg $808 2021-12-16 Buy
Ambeed A220462 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-ylcarbamate 98+% 1g $2503 2021-12-16 Buy
American Custom Chemicals Corporation INB0009843 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN 95.00% 10MG $650.27 2021-12-16 Buy
American Custom Chemicals Corporation INB0009843 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN 95.00% 50MG $752.14 2021-12-16 Buy

Properties

Melting point :201-203°C
Boiling point :797.8±60.0 °C(Predicted)
Density :1.21
RTECS :LX8932000
Flash point :>110°(230°F)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: soluble
form :solid
pka :8.62±0.70(Predicted)
color :Purple or dark red
Water Solubility :Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/mL. Very poorly soluble in water
Sensitive :Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :AYUNIORJHRXIBJ-HTLBVUBBSA-N
SMILES :C12C(=O)C(=CC(=O)C=1NCC=C)NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(=O)N)C(C)=C[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C2 |t:17,19,30|
CAS DataBase Reference :75747-14-7

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P501 Dispose of contents/container to..…

Description

Geldanamycin is a potent inhibitor of Hsp90 that exhibits severe hepatotoxicity when used in vivo. 17-AAG is an analog of geldanamycin which has potent in vivo activity and reduced toxicity. Like other Hsp90 inhibitors, 17-AAG has diverse anti-tumor actions and has potential in treating certain types of cancer. 17-AAG inhibits the growth of prostate cancer cell lines (IC50 = 25-45 nM). 17-AAG promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50 = 4-72 nM).

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