S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide
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- $62 - $2800
- Product name: S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide
- CAS: 1346574-57-9
- MF: C31H38N6O2
- MW: 526.67
- EINECS:-0
- MDL Number:
- Synonyms:GSK126;S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide;N-[(4,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-((1S)-1-methylpropyl)-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide;GSK126, >=98%;1-(S)-sec-butyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide;GSK 126 N-[(4,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-((1S)-1-methylpropyl)-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide;N-[(4,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-((1S)-1-methylpropyl)-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide GSK126;N-[(4,6-Dimethyl-2-ox
31 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Tocris
- TRC
Package
- 1mg
- 5mg
- 2x5mg
- 5
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1000mg
- 1g
- ManufacturerAK Scientific
- Product numberSYN5012
- Product descriptionGSK126
- Packaging50mg
- Price$515
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3446
- Product descriptionGSK126
- Packaging5mg
- Price$84
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3446
- Product descriptionGSK126
- Packaging10mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3446
- Product descriptionGSK126
- Packaging50mg
- Price$290
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3446
- Product descriptionGSK126
- Packaging100mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2140
- Product descriptionGSK126 98%
- Packaging5mg
- Price$121
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2140
- Product descriptionGSK126 98%
- Packaging2x5mg
- Price$176
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546178
- Product descriptionGSK-126 >98%
- Packaging5mg
- Price$190.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546178
- Product descriptionGSK-126 >98%
- Packaging25mg
- Price$596.7
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180908
- Product descriptionGSK126 >98%
- Packaging100mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180908
- Product descriptionGSK126 >98%
- Packaging250mg
- Price$1208.7
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180908
- Product descriptionGSK126 >98%
- Packaging1000mg
- Price$2395.3
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFB43076
- Product descriptionGSK 126
- Packaging10mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFB43076
- Product descriptionGSK 126
- Packaging50mg
- Price$275
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15415
- Product descriptionGSK126 ≥98%
- Packaging1mg
- Price$62
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15415
- Product descriptionGSK126 ≥98%
- Packaging5mg
- Price$120
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5012 | GSK126 | 50mg | $515 | 2021-12-16 | Buy |
| ApexBio Technology | A3446 | GSK126 | 5mg | $84 | 2021-12-16 | Buy |
| ApexBio Technology | A3446 | GSK126 | 10mg | $125 | 2021-12-16 | Buy |
| ApexBio Technology | A3446 | GSK126 | 50mg | $290 | 2021-12-16 | Buy |
| ApexBio Technology | A3446 | GSK126 | 100mg | $400 | 2021-12-16 | Buy |
| Axon Medchem | Axon2140 | GSK126 98% | 5mg | $121 | 2021-12-16 | Buy |
| Axon Medchem | Axon2140 | GSK126 98% | 2x5mg | $176 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546178 | GSK-126 >98% | 5mg | $190.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546178 | GSK-126 >98% | 25mg | $596.7 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180908 | GSK126 >98% | 100mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180908 | GSK126 >98% | 250mg | $1208.7 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180908 | GSK126 >98% | 1000mg | $2395.3 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB43076 | GSK 126 | 10mg | $95 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB43076 | GSK 126 | 50mg | $275 | 2021-12-16 | Buy |
| Cayman Chemical | 15415 | GSK126 ≥98% | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 15415 | GSK126 ≥98% | 5mg | $120 | 2024-03-01 | Buy |
Properties
Melting point :>216°C (dec.)
Boiling point :823.4±65.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
pka :11.93±0.10(Predicted)
form :Solid
color :Off-White
Boiling point :823.4±65.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
pka :11.93±0.10(Predicted)
form :Solid
color :Off-White
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
The histone H3 lysine 27 (H3K27) methyltransferase EZH2 plays an important role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer. GSK126 is a selective, S-adenosyl-methionine-competitive small molecule inhibitor of EZH2 methyltransferase activity (Ki = 0.57 nM; IC50 = 9.9 nM versus that of EZH1: Ki = 89 nM; IC50 = 680 nM). It is more than 1,000-fold selective for EZH2 over other histone methyltranferases, including both SET-domain-containing and non-SET-domain-containing methyltransferases. At concentrations of 7-252 nM, it has been shown to inhibit global H3K27 trimethylation levels and to reactivate silenced PRC2 target genes. Furthermore, GSK126 can inhibit the proliferation of EZH2 mutant DLBCL cell lines (IC50 = 28-61 nM) as well as the growth of EZH2 mutant DLBCL xenografts in mice receiving a daily dose of 50 mg/kg.Related product price
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