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ChemicalBook >> CAS DataBase List >> GSK2982772

GSK2982772

GSK2982772 price.
  • $56 - $2400
  • Product name: GSK2982772
  • CAS: 1622848-92-3
  • MF: C20H19N5O3
  • MW: 377.4
  • EINECS:
  • MDL Number:MFCD30489467
  • Synonyms:(S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide;5184;GSK2982772;RIP1 inhibitor GS2982772;CS-2502;(S)-5-BENZYL-N-(5-METHYL-4-OXO-2,3,4,5-TETRAHYDROBENZO[B][1,4]OXAZEPIN-3-YL)-4H-1,2,4-TRIAZOLE-3-CAR;GSK 2982772;GSK-2982772;1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxo-1,5-benzoxazepin-3-yl]-
28 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • Ark Pharm
  • Axon Medchem
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Crysdot
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 2x5mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number0546DY
  • Product descriptionCID77108121
  • Packaging50mg
  • Price$657
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA363017
  • Product description(S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide 99+%
  • Packaging1mg
  • Price$56
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA363017
  • Product description(S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide 99+%
  • Packaging5mg
  • Price$112
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA363017
  • Product description(S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide 99+%
  • Packaging10mg
  • Price$145
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA363017
  • Product description(S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide 99+%
  • Packaging25mg
  • Price$188
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA363017
  • Product description(S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide 99+%
  • Packaging50mg
  • Price$245
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA363017
  • Product description(S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide 99+%
  • Packaging100mg
  • Price$319
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA363017
  • Product description(S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide 99+%
  • Packaging250mg
  • Price$636
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA363017
  • Product description(S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide 99+%
  • Packaging1g
  • Price$1588
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0028658
  • Product description(S)-5-BENZYL-N-(5-METHYL-4-OXO-2,3,4,5-TETRAHYDROBENZO[B]-[1,4]OXAZEPIN-3-YL)-4H-1,2,4-TRIAZOLE-3-CARBOXAMIDE 95.00%
  • Packaging5MG
  • Price$454.73
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000067117
  • Product descriptionGSK2982772 99+%
  • Packaging10mg
  • Price$654
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000067117
  • Product descriptionGSK2982772 99+%
  • Packaging25mg
  • Price$1211
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000067117
  • Product descriptionGSK2982772 99+%
  • Packaging50mg
  • Price$2180
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2713
  • Product descriptionGSK2982772 99%
  • Packaging2x5mg
  • Price$308
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2713
  • Product descriptionGSK2982772 99%
  • Packaging25mg
  • Price$665.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBG166667
  • Product descriptionGSK 2982772
  • Packaging10mg
  • Price$250
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 0546DY CID77108121 50mg $657 2021-12-16 Buy
Ambeed A363017 (S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide 99+% 1mg $56 2021-12-16 Buy
Ambeed A363017 (S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide 99+% 5mg $112 2021-12-16 Buy
Ambeed A363017 (S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide 99+% 10mg $145 2021-12-16 Buy
Ambeed A363017 (S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide 99+% 25mg $188 2021-12-16 Buy
Ambeed A363017 (S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide 99+% 50mg $245 2021-12-16 Buy
Ambeed A363017 (S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide 99+% 100mg $319 2021-12-16 Buy
Ambeed A363017 (S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide 99+% 250mg $636 2021-12-16 Buy
Ambeed A363017 (S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide 99+% 1g $1588 2021-12-16 Buy
American Custom Chemicals Corporation API0028658 (S)-5-BENZYL-N-(5-METHYL-4-OXO-2,3,4,5-TETRAHYDROBENZO[B]-[1,4]OXAZEPIN-3-YL)-4H-1,2,4-TRIAZOLE-3-CARBOXAMIDE 95.00% 5MG $454.73 2021-12-16 Buy
Ark Pharm P000067117 GSK2982772 99+% 10mg $654 2021-12-16 Buy
Ark Pharm P000067117 GSK2982772 99+% 25mg $1211 2021-12-16 Buy
Ark Pharm P000067117 GSK2982772 99+% 50mg $2180 2021-12-16 Buy
Axon Medchem Axon2713 GSK2982772 99% 2x5mg $308 2021-12-16 Buy
Axon Medchem Axon2713 GSK2982772 99% 25mg $665.5 2021-12-16 Buy
Biosynth Carbosynth BG166667 GSK 2982772 10mg $250 2021-12-16 Buy

Properties

Density :1.40±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :solid
pka :8.80±0.40(Predicted)
color :Off-white
Stability :Stable for 2 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

(S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide, also known as GSK2982772, is a first-in-class receptor interacting protein 1(RIP1)-kinase specific clinical candidate for the treatment of inflammatory disease. It is an inhibitor of RIP1 that regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including immune-mediated inflammatory diseases. It has excellent activity in blocking many TNF-dependent cellular responses. Highlighting its potential as a novel anti-inflammatory agent, the inhibitor was also able to reduce spontaneous production of cytokines from human ulcerative colitis explants.