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ChemicalBook >> CAS DataBase List >> 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one

9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one

9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one price.
  • $65 - $6254
  • Product name: 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one
  • CAS: 1223001-51-1
  • MF: C24H15F3N4O
  • MW: 432.4
  • EINECS:
  • MDL Number:MFCD18782652
  • Synonyms:9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one;9-(6-AMino-pyridin-3-yl)-...;9-(6-AMino-pyridin-3-yl)-1-(3-trifluoroMethyl-phenyl)-1H-benzo[h][1,6]naphthyridin-2-one;Torin 2, Free Base, >99%;Benzo[h]-1,6-naphthyridin-2(1H)-one, 9-(6-amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-;9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one Torin 2;Torin 2 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one;9-(6-AMINOPYRIDIN-3-YL)-1-[3-(TRIFLUOROMETHYL)PHENYL]BENZO[H][1,6]NAPHTHYRIDIN-2-ONE
31 prices
Selected condition：
Brand
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 50
  • 250mg
  • 1g
  • ManufacturerApexBio Technology
  • Product numberB1640
  • Product descriptionTorin2
  • Packaging50mg
  • Price$314
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60269
  • Product descriptionTorin2
  • Packaging10mg
  • Price$248
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1834
  • Product descriptionTorin2 99%
  • Packaging25mg
  • Price$330
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146132
  • Product descriptionTorin2 >98%
  • Packaging100mg
  • Price$838.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146132
  • Product descriptionTorin2 >98%
  • Packaging250mg
  • Price$1504.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146132
  • Product descriptionTorin2 >98%
  • Packaging1g
  • Price$2839
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFT102223
  • Product descriptionTorin 2
  • Packaging10mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFT102223
  • Product descriptionTorin 2
  • Packaging50mg
  • Price$472.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14185
  • Product descriptionTorin 2 ≥98%
  • Packaging5mg
  • Price$86
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14185
  • Product descriptionTorin 2 ≥98%
  • Packaging10mg
  • Price$161
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14185
  • Product descriptionTorin 2 ≥98%
  • Packaging25mg
  • Price$336
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0236
  • Product descriptionTorin2 99.93%
  • Packaging5mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0236
  • Product descriptionTorin2 99.93%
  • Packaging10mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0236
  • Product descriptionTorin2 99.93%
  • Packaging50mg
  • Price$330
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0236
  • Product descriptionTorin2 99.93%
  • Packaging100mg
  • Price$490
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0236
  • Product descriptionTorin2 99.93%
  • Packaging200mg
  • Price$846
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ApexBio Technology B1640 Torin2 50mg $314 2021-12-16 Buy
Arctom CFN60269 Torin2 10mg $248 2021-12-16 Buy
Axon Medchem Axon1834 Torin2 99% 25mg $330 2021-12-16 Buy
Biorbyt Ltd orb146132 Torin2 >98% 100mg $838.1 2021-12-16 Buy
Biorbyt Ltd orb146132 Torin2 >98% 250mg $1504.5 2021-12-16 Buy
Biorbyt Ltd orb146132 Torin2 >98% 1g $2839 2021-12-16 Buy
Biosynth Carbosynth FT102223 Torin 2 10mg $135 2021-12-16 Buy
Biosynth Carbosynth FT102223 Torin 2 50mg $472.5 2021-12-16 Buy
Cayman Chemical 14185 Torin 2 ≥98% 5mg $86 2024-03-01 Buy
Cayman Chemical 14185 Torin 2 ≥98% 10mg $161 2024-03-01 Buy
Cayman Chemical 14185 Torin 2 ≥98% 25mg $336 2024-03-01 Buy
ChemScene CS-0236 Torin2 99.93% 5mg $65 2021-12-16 Buy
ChemScene CS-0236 Torin2 99.93% 10mg $110 2021-12-16 Buy
ChemScene CS-0236 Torin2 99.93% 50mg $330 2021-12-16 Buy
ChemScene CS-0236 Torin2 99.93% 100mg $490 2021-12-16 Buy
ChemScene CS-0236 Torin2 99.93% 200mg $846 2021-12-16 Buy

Properties

Melting point :>275° C (dec.)
Boiling point :623.7±55.0 °C(Predicted)
Density :1.427
storage temp. :2-8°C
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
form :powder
pka :5.66±0.26(Predicted)
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM in p53?/? MEFs cell line; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM,in PC3 cell lines respectively.

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