4-Nitrobenzoyl chloride
Product identifier
- Product name: 4-Nitrobenzoyl chloride
- CBnumber: CB2182076
- CAS: 122-04-3
- EINECS Number: 204-517-4
- Synonyms: 4-Nitrobenzoyl chloride,p-Nitrobenzoyl chloride
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: 4-Nitrobenzoyl chloride
- Synonyms: 4-Nitrobenzoyl chloride,p-Nitrobenzoyl chloride
- CAS: 122-04-3
- EC number: 204-517-4
- MF: C7H4ClNO3
- MW: 185.56
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
Further information
No data available
NFPA 704
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 2 | Undergoes violent chemical change at elevated temperatures and pressures, reacts violently with water, or may form explosive mixtures with water (e.g. white phosphorus, potassium, sodium) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Keep container tightly closed in a dry and well-ventilated place. Store in cool place. Moisture sensitive.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Appropriate engineering controlsHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm Break through time: 480 min
Material tested:Dermatril? (KCL 740 / Aldrich Z677272, Size M)
Splash contact Material: Nitrile rubber
Minimum layer thickness: 0,11 mm Break through time: 480 min
Material tested:Dermatril? (KCL 740 / Aldrich Z677272, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Where risk assessment shows air-purifying respirators are appropriate use a full- face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Do not let product enter drains.
Information on basic physicochemical properties
- Appearanceyellowyellow crystalline
- Odourstinging
- Odour ThresholdNo data available
- pHNo data available
- Melting point/freezing pointMelting point/range: 71 - 74 °C - lit.
- Initial boiling point and boiling range202 - 205 °C at 140 hPa - lit.
- Flash point102 °C - closed cup
- Evaporation rateNo data available
- Flammability (solid, gas)No data available
- Upper/lower flammability or explosive limitsNo data available
- Vapour pressureNo data available
- Vapour densityNo data available
- Relative densityNo data available
- Water solubility(decomposition)
- Partition coefficient: n-octanol/waterlog Pow: 1,25 - Bioaccumulation is not expected.
- Autoignition temperatureNo data available
- Decomposition temperatureNo data available
- ViscosityNo data available
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
Other safety information
Solubility in other solvents
Alcohol at 20 °C
-
decomposes Ether at 20 °C
-
soluble
Reactivity
No data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
No data available
Conditions to avoid
Avoid moisture.
Incompatible materials
Water, Alcohols, Oxidizing agents, Strong bases
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas
Other decomposition products - No data available In the event of fire: see section 5
Information on toxicological effects
Acute toxicityRemarks: Behavioral:Muscle weakness. Behavioral:Ataxia. Behavioral:Muscle contraction or spasticity.
Salmonella typhimurium Result: positive
Ames test
Escherichia coli/Salmonella typhimurium
Result: Positive results were obtained in some in vitro tests. Mutagenicity (mammal cell test):
Result: negative (Lit.)
Acute inhalation toxicity - mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., Cough, Shortness of breath, Headache, Nausea
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Decomposition of the substance with tissue moisture.
The following applies to aromatic nitro compounds in general: systemic effect: methaemoglobinaemia with headache, cardiac dysrhythmias, drop in blood pressure, dyspnoea, and spasms; principal sign: cyanosis (blue discolouration of the blood).
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Toxicity
Persistence and degradability
Bioaccumulative potential
Mobility in soil
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
Discharge into the environment must be avoided.
Stability in water
Remarks: Hydrolyses on contact with water.
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Waste material must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.
Contaminated packaging
Dispose of as unused product.
UN number
ADR/RID: 3261 IMDG: 3261 IATA: 3261
UN proper shipping name
ADR/RID: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S. (4-Nitrobenzoyl chloride) IMDG: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S. (4-Nitrobenzoyl chloride)
IATA: Corrosive solid, acidic, organic, n.o.s. (4-Nitrobenzoyl chloride)
Transport hazard class(es)
ADR/RID: 8 IMDG: 8 IATA: 8
Packaging group
ADR/RID: II IMDG: II IATA: II
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
No data available
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.