2-Chlorotoluene
Product identifier
- Product name: 2-Chlorotoluene
- CBnumber: CB9245073
- CAS: 95-49-8
- EINECS Number: 202-424-3
- Synonyms: OCT,2-CHLOROTOLUENE
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Acute toxicity - Category 4, Inhalation
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
Label elements
Pictogram(s)
- Signal wordDanger
H225 Highly Flammable liquid and vapour
H226 Flammable liquid and vapour
H332 Harmful if inhaled
H335 May cause respiratory irritation
H336 May cause drowsiness or dizziness
H360 May damage fertility or the unborn child
H361 Suspected of damaging fertility or the unborn child
H370 Causes damage to organs
H373 May cause damage to organs through prolonged or repeated exposure
H400 Very toxic to aquatic life
H401 Toxic to aquatic life
H411 Toxic to aquatic life with long lasting effects
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P391 Collect spillage. Hazardous to the aquatic environment
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to..…
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P317 Get medical help.
P391 Collect spillage.
none
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: 2-Chlorotoluene
- Synonyms: OCT,2-CHLOROTOLUENE
- CAS: 95-49-8
- EC number: 202-424-3
- MF: C7H7Cl
- MW: 126.58
Description of first aid measures
If inhaledFresh air, rest. Refer for medical attention.
First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .
Most important symptoms and effects, both acute and delayed
Inhalation of vapor may cause respiratory irrtation. Prolonged and repeated vapor exposures may produce systemic toxic effects. (USCG, 1999)
Indication of any immediate medical attention and special treatment needed
Absorption, Distribution and ExcretionApplied under occlusive dressing to 2 guinea pigs ... there was ... evidence of skin absorption ...
Extinguishing media
If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. Chlorotoluenes
Specific Hazards Arising from the Chemical
Special Hazards of Combustion Products: May contain toxic chloride fumes. Behavior in Fire: Container may explode in heat of fire. Vapor may travel to a source of ignition and flashback. Vapor explosion hazard indoors, outdoors or in sewer. Toxic chloride fumes may be produced. (USCG, 1999)
Advice for firefighters
Use water spray, carbon dioxide, foam, powder. In case of fire: keep drums, etc., cool by spraying with water.
NFPA 704
| HEALTH | |||
| FIRE | 2 | Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.
Environmental precautions
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
Precautions for safe handling
NO open flames, NO sparks and NO smoking. Above 43°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Fireproof. Separated from strong oxidants.
Control parameters
Occupational Exposure limit valuesTLV: 50 ppm as TWA
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear safety spectacles.
Protective gloves.
Use ventilation, local exhaust or breathing protection.
no data available
Information on basic physicochemical properties
- Physical stateLiquid
- ColourClear
- Odour
Aromatic odor.
- Melting point/freezing point
-35.6 °C.
- Boiling point or initial boiling point and boiling range
159.2 °C. Atm. press.:1 013 hPa.
- Flammability
Class IC Flammable Liquid: Fl.P. at or above 73°F and below 100°F.
- Lower and upper explosion limit/flammability limit1.0-12.6%(V)
- Flash point
43 °C.
- Auto-ignition temperature
> 500 °C.
- Decomposition temperature
no data available
- pH
no data available
- Kinematic viscosity
dynamic viscosity (in mPa s) = 1.022. Temperature:20°C.
- SolubilityH2O: slightly soluble0.047g/L at 20°C
- Partition coefficient n-octanol/water
log Pow = 3.185.
- Vapour pressure10 mm Hg ( 43 °C)
- Density and/or relative density
1.08. Temperature:20 °C.
- Relative vapour density
4.38 (vs air)
- Particle characteristics
no data available
Reactivity
On combustion, forms toxic and corrosive fumes including hydrogen chloride and phosgene. Reacts with oxidants.
Chemical stability
no data available
Possibility of hazardous reactions
SLIGHT, WHEN EXPOSED TO HEAT OR FLAME. /4-CHLOROTOLUENE/O-CHLOROTOLUENE may be incompatible with strong oxidizing and reducing agents. Also may be incompatible with amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. Reacts violently with dimethyl sulfoxide (NTP, 1992).
Conditions to avoid
no data available
Incompatible materials
Acids, alkalis, oxidizers, reducing materials, water.
Hazardous decomposition products
no data available
Acute toxicity
- Oral: LD50 - rat (male) - 3 227 mg/kg bw.
- Inhalation: LC50 - rat (male) - 7 119 ppm.
- Dermal: LD50 - rat (male/female) - > 1 080 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is irritating to the eyes, skin and respiratory tract.
STOT-repeated exposure
The substance defats the skin, which may cause dryness or cracking.
Aspiration hazard
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.
Toxicity
- Toxicity to fish: LC50 - Oryzias latipes - 7.7 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 0.7 mg/L - 48 h.
- Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - 7.8 mg/L - 72 h.
- Toxicity to microorganisms: TT - Pseudomonas putida - 15 mg/L - 16 h.
Persistence and degradability
In the Japanese MITI test, using an initial concn of 100 ppm 2-chlorotoluene, <30% of the theoretical BOD was reached in 14 days using an activated sludge inoculum(1,2). In the modified MITI test, using an initial concentration of 100 ppm 2-chlorotoluene, 0% of the theoretical BOD was reached in 14 days(3). A second order rate constant for the microbial degradation of 2-chlorotoluene in natural water was experimentally determined to be 2.7X10-11 L/organism-hr(4). Microorganisms capable of degrading 2-chlorotolune were isolated from soil samples collected at a landfill site used for the disposal of chlorinated organic wastes(5). A microbial blend of 10 different bacteria and 2 fungi was used to degrade 2-chlorotoluene at a concentration of 200 mg/l; complete biodegradation occurred in 3 days(6).
Bioaccumulative potential
Carp exposed to 2-chlorotoluene at 0.045 and 0.45 mg/L had measured BCF values of 20-112 and 41.6-87.2, respectively(1). An estimated BCF value of 230 was calculated for 2-chlorotoluene(SRC), using a measured log Kow of 3.42(2) and a recommended regression-derived equation(3). According to a recommended classification scheme(4), these BCF values suggest that bioconcentration of 2-chlorotoluene in aquatic organisms may occur(SRC).
Mobility in soil
Measured soil adsorption coefficients (Koc) for 2-chlorotoluene ranged between 170-880, the average value was 370(1). According to a recommended classification scheme(3), these Koc values suggest that 2-chlorotoluene will have low to moderate mobility in soil(2,SRC).
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: UN2238 (For reference only, please check.)
IMDG: UN2238 (For reference only, please check.)
IATA: UN2238 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: CHLOROTOLUENES (For reference only, please check.)
IMDG: CHLOROTOLUENES (For reference only, please check.)
IATA: CHLOROTOLUENES (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 3 (For reference only, please check.)
IMDG: 3 (For reference only, please check.)
IATA: 3 (For reference only, please check.)
Packing group, if applicable
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.