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Oxidative Medicine and Cellular Longevity

Oxidative Medicine and Cellular Longevity

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Therapeutic Potential of Isoflavones with an Emphasis on Daidzein.

Published:9 September 2021 DOI: 10.1155/2021/6331630 PMID: 34539970
Mohammed M Alshehri,?Javad Sharifi-Rad,?Jesús Herrera-Bravo,?Evelyn L Jara,?Luis A Salazar,?Dorota Kregiel,?Yadav Uprety,?Muhammad Akram,?Mehwish Iqbal,?Miquel Martorell,?Margalida Torrens-Mas,?Daniel Gabriel Pons,?Sevgi Durna Da?tan,?Natália Cruz-Martins,?Fethi Ahmet Ozdemir,?Manoj Kumar,?William C Cho

Abstract

Daidzein is a phytoestrogen isoflavone found in soybeans and other legumes. The chemical composition of daidzein is analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with estrogen and estrogen receptor (ER) complex. Hence, daidzein puts forth shielding effects against a great number of diseases, especially those associated with the control of estrogen, such as breast cancer, diabetes, osteoporosis, and cardiovascular disease. However, daidzein also has other ER-independent biological activities, such as oxidative damage reduction acting as an antioxidant, immune regulator as an anti-inflammatory agent, and apoptosis regulation, directly linked to its potential anticancer effects. In this sense, the present review is aimed at providing a deepen analysis of daidzein pharmacodynamics and its implications in human health, from its best-known effects alleviating postmenopausal symptoms to its potential anticancer and antiaging properties.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
Daidzein 486-66-8 C15H10O4 649 suppliers $5.00-$12190.00

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