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Journal of veterinary pharmacology and therapeutics

Journal of veterinary pharmacology and therapeutics

IF: 1.5
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Pharmacokinetics of neomycin sulfate after intravenous and oral administrations in swine

Published:24 June 2021 DOI: 10.1111/jvp.12981 PMID: 34165196
Yu Liu, Yuxin Yang, Yuying Cao, Jicheng Qiu, Jingyuan Kong, Lu Zhang, Yanying Guo, Mingchuan Zhang, Xingyuan Cao, Suxia Zhang

Abstract

The aminoglycoside antibiotic neomycin, which is used to treat external or internal bacterial infections, is primarily administered in veterinary medicine as a sulfate salt. However, no information is available on the pharmacokinetic characteristics and absolute availability of neomycin sulfate after intravenous (i.v.) and oral (p.o.) administrations in swine. Here, these parameters were studied in swine after i.v. and p.o. doses of single 15?mg/kg body weight doses. The blood samples were assessed using ultra-high-performance liquid chromatography-tandem mass/mass spectrometry (UPLC-MS/MS) and pharmacokinetic parameters were analyzed using a non-compartmental model. In swine, after the p.o. administration, the elimination half-life, mean residue time from t0 to the last collection point, mean maximum concentration, mean time to reach maximum concentration and area under concentration–time curve from t0 to the last collection point values were 12.43 ± 7.63?h, 10.25 ± 4.32?h, 0.11 ± 0.07?μg/ml, 1.92 ± 0.97?h and 1.23 ± 0.78?μg·h/ml, respectively, whereas after the i.v. administration, the values were 5.87 ± 1.12?h, 6.07 ± 0.49?h, 15.80 ± 1.32?μg/ml, 0.30 ± 0.38?h and 76.14 ± 3.52?μg·h/ml, respectively. The absolute bioavailability of neomycin sulfate B was 4.84%±0.03.

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Neomycin sulfate 1405-10-3 C23H48N6O17S 793 suppliers $5.00-$1651.10

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