成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook >> journal list >> Journal of Pharmacy and Pharmacology >>article
Journal of Pharmacy and Pharmacology

Journal of Pharmacy and Pharmacology

IF: 2.79
Download PDF

Identification of Urinary Metabolites of Clemastine after Oral Administration to Man

Published:18 February 2010 DOI: 10.1211/0022357991772097 PMID: 10197418
Man Ho Choi, Byung Hwa Jung, Bong Chul Chung

Abstract

The metabolism of clemastine, 2-{2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine, has been studied in three adult male volunteers after a single oral dose of 20 mg as the fumarate. After enzymatic hydrolysis solvent extracts of urine were derivatized with N-methyl-N-trimethylsilyltrifluoroacetamide-ammonium iodide and analysed by gas chromatography-mass spectrometry. The structures of metabolites were determined on the basis of electron impact and chemical ionization mass spectra and the identities of some (e.g. carbinol, 4-chlorobenzophenone and 4-chlorophenylstyrene) were confirmed by use of authentic standards.

The principal route of metabolism of clemastine in man involves direct oxidation, O-dealkylation (fission of the ether bond), aromatic hydroxylation, aliphatic oxidation, alcoholic dehydration, and then enzymatic hydrolysis. Of the total amount of metabolites excreted in the urine 35% was carbinol (metabolite M3, major metabolite), 15% was M1, 17% was M2, 11% was M4, 9% was M5, 8% was M6 and 5% was M7.

Substances (6)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Methanol 67-56-1 CH4O 832 suppliers $9.00-$7620.00
4-Chlorobenzophenone 134-85-0 C13H9ClO 727 suppliers $5.00-$596.00
1-Methylpyrrolidine 120-94-5 C5H11N 485 suppliers $8.00-$1225.00
CLEMASTINE FUMARATE 15686-51-8 C21H26ClNO 66 suppliers Inquiry
CRUDE IODIDE 5 suppliers Inquiry
FUMARATE 142-42-7 C4H2O4-2 2 suppliers Inquiry

Similar articles

IF:0

Brain histamine H1 receptor occupancy measured by PET after oral administration of desloratadine and loratadine

Proceedings for Annual Meeting of The Japanese Pharmacological Society Tadaho Nakamura,?K. Hiraoka,etc Published: 1 January 2019
IF:2.7

Pharmacokinetics of Memantine after a Single and Multiple Dose of Oral and Patch Administration in Rats

Basic & Clinical Pharmacology & Toxicology Soo-Han Lee, Seung-Hyun Kim,etc Published: 27 August 2015
IF:2.9

Urinary metabolites of the UV filter 2-Ethylhexyl salicylate as biomarkers of exposure in humans

Toxicology letters Daniel Bury , Peter Griem ,etc Published: 1 July 2019