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Biotechnology Letters

Biotechnology Letters

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Itaconic acid production in microorganisms.

Published:1 March 2018 DOI: 10.1007/s10529-017-2500-5 PMID: 29299715
Meilin Zhao, Xinyao Lu, Hong Zong, Jinyang Li, Bin Zhuge

Abstract

Itaconic acid, 2-methylidenebutanedioic acid, is a precursor of polymers, chemicals, and fuels. Many fungi can synthesize itaconic acid; Aspergillus terreus and Ustilago maydis produce up to 85 and 53?g?l-1, respectively. Other organisms, including Aspergillus niger and yeasts, have been engineered to produce itaconic acid. However, the titer of itaconic acid is low compared with the analogous major fermentation product, citric acid, for which the yield is >?200?g?l-1. Here, we review two types of pathway for itaconic acid biosynthesis as well as recent advances by metabolic engineering strategies and process optimization to enhance itaconic acid productivity in native producers and heterologous hosts. We also propose further improvements to overcome existing problems.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Citric acid 77-92-9 C6H8O7 1797 suppliers $5.00-$2290.00
Itaconic acid 97-65-4 C5H6O4 647 suppliers $5.00-$6711.36

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