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Annual review of nutrition

Annual review of nutrition

IF: 12.6
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Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite.

Published:1 January 2015 DOI: 10.1146/annurev-nutr-071714-034243 PMID: 25974697
Thekla Cordes, Alessandro Michelucci, Karsten Hiller

Abstract

Itaconic acid is well known as a precursor for polymer synthesis and has been involved in industrial processes for decades. In a recent surprising discovery, itaconic acid was found to play a role as an immune-supportive metabolite in mammalian immune cells, where it is synthesized as an antimicrobial compound from the citric acid cycle intermediate cis-aconitic acid. Although the immune-responsive gene 1 protein (IRG1) has been associated to immune response without a mechanistic function, the critical link to itaconic acid production through an enzymatic function of this protein was only recently revealed. In this review, we highlight the history of itaconic acid as an industrial and antimicrobial compound, starting with its biotechnological synthesis and ending with its antimicrobial function in mammalian immune cells.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Itaconic acid 97-65-4 C5H6O4 646 suppliers $5.00-$6711.36
CIS-ACONITIC ACID 585-84-2 C6H6O6 169 suppliers $30.00-$985.00

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