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Current clinical pharmacology

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Dutasteride in Androgenetic Alopecia: An Update.

Published:1 January 2017 DOI: 10.2174/1574884712666170310111125 PMID: 28294070
Tasleem Arif, Konchok Dorjay, Mohammad Adil, Marwa Sami

Abstract

Background: Androgenetic alopecia is a common condition characterized by thinning of scalp hair. Conversion of testosterone to dihydrotestosterone, a more potent androgen, by the enzyme 5-α-reductase is responsible for underlying pathogenesis. Dutasteride, a synthetic 4-azasteroid, is a selective and competitive inhibitor of both type-1 and type-2 isoenzymes of 5-α-reductase. Finasteride and minoxidil are the only approved drugs for androgenetic alopecia. Dutasteride has been demonstrated to be effective in several randomized, double-blind, placebo controlled trials in androgenetic alopecia. In this review, after the pharmacology of dutasteride, the authors have discussed the status of dutasteride in androgenetic alopecia and have compared its efficacy with that of finasteride.

Objective: This article aims to review the current status of dutasteride in androgenetic alopecia. The structure, mechanism of action, pharmacokinetics and side effects are discussed along with its comparison with finasteride in androgenetic alopecia.

Method: The main sources of our information were Medline Pubmed, Google scholar and Scopus including original articles and review articles. The keywords 'dutasteride', 'dutasteride in androgenetic alopecia' were used for search.

Conclusion: Like finasteride, dutasteride is now becoming popular treatment option in AGA, due to its good response shown by various randomized control studies and meta-analysis. Also, in most of these studies, dutasteride was found to be better than finasteride with comparable adverse effects. Therefore, dutasteride could become a treatment of choice for AGA in near future.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Finasteride 98319-26-7 C23H36N2O2 801 suppliers $26.00-$845.00
Minoxidil 38304-91-5 C9H15N5O 779 suppliers $7.00-$941.00
Dutasteride 164656-23-9 C27H30F6N2O2 622 suppliers $50.00-$1732.50

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