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Journal of molecular and cellular cardiology

Journal of molecular and cellular cardiology

IF: 4.9
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MAPK14/AIFM2 pathway regulates mitophagy-dependent apoptosis to improve atrial fibrillation

Published:8 December 2024 DOI: 10.1016/j.yjmcc.2024.12.002 PMID: 39657863
Lu Wang,?Wanyue Sang,?Yi Jian,?Yafan Han,?Feifei Wang,?Subinuer Wubulikasimu,?Li Yang,?Baopeng Tang,?Yaodong Li

Abstract

Objectives: To investigate the role and mechanism of MAPK14/AIFM2 pathway in Ang II-induced atrial fibrillation in rats.

Methods: A rat model of AF was established for in vivo experiments and HL-1 cells were treated with Ang II to develop an in vitro model. In addition, HL1 cells overexpressing AIFM2 (oeAIFM2) were constructed. SB203580 was used to inhibit the expression of MAPK14. The role of MAPK14 in Ang II-AF model was investigated by in vivo electrophysiological examination and molecular biology tests. The role of MAPK14 / AIFM2 pathway on AF induced by Ang II was explored in vitro.

Results: MAPK14 and AIFM2 were significantly up-regulated in AF induced by Ang II (all P?

Conclusions: Inhibition of the MAPK14/AIFM2 pathway improved Ang II-induced AF by inhibiting mitophagy-dependent apoptosis.

Substances (1)

Materials
Procduct Name CAS Molecular Formula Supplier Price
SB 203580 152121-47-6 C21H16FN3OS 244 suppliers $26.00-$2151.00

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