木香烴內(nèi)酯|T2902|TargetMol

價(jià)格	￥179	￥387	￥555
包裝	1mg	5mg	10mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱:木香烴內(nèi)酯	英文名稱:Costunolide
CAS:553-21-9	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 91.75%	產(chǎn)品類別: 抑制劑
貨號(hào): T2902

Product Introduction

Bioactivity

名稱	Costunolide
描述	Costunolide (Costus lactone) has anti-inflammatory and anti-oxidant properties and mediates apoptosis.
細(xì)胞實(shí)驗(yàn)	1) Plate 500-10,000 cells in 200 μL media per well in a 96 well plate. Leave 8 wells empty for blank controls. 2) Incubate (37 °C, 5% CO2) overnight to allow the cells to attach to the wells. 3) Add 2 μL of Costunolide dissolved in DMSO to each well. Place on a shaking table, 150 rpm for 5 minutes, to thoroughly mix the samples into the media. 5) Incubate (37 °C, 5% CO2) for 48 hours to allow Costunolide to take effect. 6) Make 2 mL or more of MTT solution per 96 well plate at 5 mg/mL in PBS. Do not make a stock as MTT in solution is not stable long-term. 7) Add 20 μL MTT solution to each well. Place on a shaking table, 150 rpm for 5 minutes, to thoroughly mix the MTT into the media. 8) Incubate (37 °C, 5% CO2) for 1-5 hours to allow the MTT to be metabolized. 9) Dump off the media. (Dry plate on paper towels to remove residue if necessary. 10) Resuspend formazan (MTT metabolic product) in 200 μL DMSO. Place on a shaking table, 150 rpm for 5 minutes, to thoroughly mix the formazan into the solvent. 11) Read optical density at 560 nm and subtract background at 670 nm. Optical density should be directly correlated with cell quantity. (Only for Reference)
激酶實(shí)驗(yàn)	Telomerase activity assay: The telomerase activity is measured by the TRAP assay using the TRAPez Telomerase Detection Kit, which includes primers of a 36-bp internal control (IC) for quantifying the amplification of telomerase activity within a linear range close to 2.5 logs. For RNase treatment, 10μL of extract are incubated with 1μg of RNase at 37 °C for 20 minutes. The products of the TRAP assay are resolved by electrophoresis in a nondenaturing12% PAGE in a buffer containing 0.5 × Tris–borate EDTA and detected by autoradiograph. For quantification of TRAP products, the dried gels are exposed to Fuji Imaging Plate at room temperature. Results are corrected for background, and a standard value of 100 is given to the untreated control cell signal. Signal intensities of Costunolide-treated cells are compared to the standard and are expressed as a fraction of the maximum value of 100. [1]
體外活性	Costunolide可降低小鼠角膜微囊模型中由乙烯基酯樹脂鱗片膠泥誘導(dǎo)的新生血管形成.Costunolide通過(guò)阻斷血管生長(zhǎng)因子信號(hào)轉(zhuǎn)導(dǎo)通路來(lái)抑制血管生成.
體內(nèi)活性	Costunolide連續(xù)處理人腫瘤細(xì)胞(A549,SK-OV-3,SK-MEL-2,XF498和HCT-1)48小時(shí),可以劑量依賴性抑制細(xì)胞增殖。Costunolide通過(guò)ROS介導(dǎo)的線粒體通透性轉(zhuǎn)換和細(xì)胞色素C在HL-60人類白血病細(xì)胞中釋放細(xì)胞溶質(zhì)來(lái)誘導(dǎo)細(xì)胞凋亡。Costunolide具有明顯的抗真菌活性,包括毛癬菌、猴毛癬菌,紅色毛癬菌等。Costunolide抑制MCF-7和MDA-MB-231端粒酶活性和細(xì)胞增殖,該抑制作用呈濃度和時(shí)間依賴性。Costunolide也劑量依賴性抑制由法尼基蛋白轉(zhuǎn)移酶誘導(dǎo)的人核纖層蛋白B法尼基化過(guò)程。
存儲(chǔ)條件	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 45 mg/mL (193.7 mM) Ethanol : 11.6 mg/mL (50 mM)
關(guān)鍵字	Inhibitor \| Apoptosis \| antioxidants \| anti-allergic \| regenerating \| anticancer \| antimicrobial \| antidiabetic \| Costunolide \| anti-inflammatory \| Endogenous Metabolite \| growth \| bone \| NSC106404 \| neuroprotective \| NSC-106404 \| promoting \| inhibit \| hair
相關(guān)產(chǎn)品	Oleamide \| Guanidine hydrochloride \| Naringin \| Daidzein \| Glycerol \| Sucrose \| Ferulic Acid \| Dextran sulfate sodium salt (MW 4500-5500) \| 3-Indoleacetic acid \| Stavudine \| Thymidine \| Fumaric acid
相關(guān)庫(kù)	神經(jīng)保護(hù)化合物庫(kù) \| 經(jīng)典已知活性庫(kù) \| 抗癌活性化合物庫(kù) \| 已知活性化合物庫(kù) \| 植物來(lái)源化合物庫(kù) \| 古代經(jīng)典名方目錄分子庫(kù) \| 抗癌天然產(chǎn)物庫(kù) \| 抗衰老化合物庫(kù) \| 天然產(chǎn)物庫(kù) \| 中藥單體化合物庫(kù)

關(guān)鍵字：木香烴內(nèi)酯|||NSC 106404|||Costus lactone|||Costunolid|||(+)-Costunolide|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過(guò)在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過(guò)五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬(wàn)人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國(guó)（陶術(shù)生物）

VIP 12年

公司成立：12年
注冊(cè)資本：566.2651萬(wàn)人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫(kù)，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

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