Mouse MMP-8 Protein, His Tag (active enzyme, MALS verified)
分子別名(Synonym)
CLG1 Protein, HNC Protein, MMP-8 Protein, PMNL-CL Protein,
表達(dá)區(qū)間及表達(dá)系統(tǒng)(Source)
Mouse MMP-8 Protein, His Tag (MM8-M52H7) is expressed from human 293 cells (HEK293). It contains AA Phe 21 - Gly 262 (Accession # O70138-1).
Predicted N-terminus: Phe 21
蛋白結(jié)構(gòu)(Molecular Characterization)
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This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 28.9 kDa. The protein migrates as 35-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑(Formulation)
Supplied as 0.2 μm filtered solution in 25 mM MES, 150 mM NaCl, 20% Glycerol, pH5.5 with trehalose as protectant.
Contact us for customized product form or formulation.
運(yùn)輸(Shipping)
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存儲(chǔ)(Storage)
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
The product MUST be stored at -70°C or lower upon receipt;
-70°C for 3 months under sterile conditions.
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背景(Background)
基質(zhì)金屬蛋白酶-8(MMP-8)也稱為中性粒細(xì)胞膠原酶和CLG1,是基質(zhì)金屬蛋白酶(MMPs)家族的成員,可降解細(xì)胞外基質(zhì)(ECM)的成分,在各種生理過程和病理過程中發(fā)揮重要作用。MMP-8可能通過保護(hù)乳腺癌癥細(xì)胞免受淋巴結(jié)轉(zhuǎn)移而影響其轉(zhuǎn)移行為,這突出了抗靶點(diǎn)鑒定在藥物開發(fā)中的重要性。腫瘤中的MMP-8可能對(duì)淋巴結(jié)轉(zhuǎn)移具有保護(hù)作用。
關(guān)鍵字: MMP-8;MMP-8蛋白;MMP-8重組蛋白;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。