白鮮堿|T5746|TargetMol

價(jià)格	￥670
包裝	20mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱:白鮮堿	英文名稱:Dictamine
CAS:484-29-7	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.72%	產(chǎn)品類別: 抑制劑
貨號(hào): T5746

Product Introduction

Bioactivity

名稱	Dictamine
描述	Dictamine (Dectamine) shows anticholinesterase, anti-inflammatory, mutagenic, and has antimicrobial activity against bacteria and fungi. It has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells.
激酶實(shí)驗(yàn)	Commercial oligonucleotide microarrays were used to determine the global transcriptional response of S. cerevisiae triggered by treatment with dictamnine. We interpreted our microarray data using the hierarchical clustering tool, T-profiler. Several major transcriptional responses were induced by dictamnine. The first was the induced environmental stress response, mainly under the control of the Msn2p and Msn4p transcription factors, and the repressed environmental stress response in genes containing the PAC (RNA polymerase A and C box) and rRPE (ribosomal RNA processing element) motifs. The second was the Upc2p-mediated response involved in lipid biosynthesis. The third comprised the PDR3- and RPN4-mediated responses involved in multidrug resistance (MDR). Finally, the TBP-mediated response was induced with dictamnine treatment. TBP is an essential general transcription factor involved in directing the transcription of genes. Quantitative real-time RT-PCR was performed on selected genes to verify the microarray results. Furthermore, morphological transitions during dictamnine exposure to S. cerevisiae L1190 (MATa/alpha) were examined, using confocal laser microscopy[1].
動(dòng)物實(shí)驗(yàn)	High performance centrifugal partition chromatography method was used for separation of the essential dictamnine,and anti-inflammatory effects of ethanol extracts and dictamnine were investigated by xylene-induced aruical swelling in mice and the abdominal capillary permeability in mice[3].
體外活性	Dictamnine 對(duì)模型真菌釀酒酵母具有抗菌活性，最小抑菌濃度(MIC)為64 microg/ml[1]。低濃度下Dictamnine(Dic)誘導(dǎo)S期細(xì)胞周期停滯，而高濃度下誘導(dǎo)細(xì)胞凋亡，此過程中未涉及線粒體膜電位(Δψmm)的喪失。使用特異性抑制劑z-DQMD-fmk抑制caspase-3并未減弱Dic誘導(dǎo)的凋亡。與僅用Dic處理相比，DHA與Dic的聯(lián)合處理顯著提高了凋亡細(xì)胞死亡率。預(yù)處理z-DQMD-fmk顯著降低了DHA與Dic共同誘導(dǎo)的凋亡，暗示caspase-3在Dic與DHA共同誘導(dǎo)的細(xì)胞凋亡中起重要作用。Dic在低濃度下誘導(dǎo)S期細(xì)胞周期停滯，在高濃度下誘導(dǎo)細(xì)胞凋亡，此過程中未涉及線粒體和caspase，而DHA通過依賴caspase的途徑增強(qiáng)了Dic誘導(dǎo)的A549細(xì)胞凋亡[2]。
體內(nèi)活性	Dictamnine在多種抗炎動(dòng)物模型中顯示出不同的抗炎效果[3]。
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 50 mg/mL (250.99 mM)
關(guān)鍵字	Fungal \| inhibit \| Bacterial \| Dictamine \| Inhibitor \| Apoptosis
相關(guān)產(chǎn)品	Dehydroacetic acid sodium \| Doxycycline \| Methyl anthranilate \| Neomycin sulfate \| Geraniol \| Dimethyl sulfoxide \| Dextran sulfate sodium salt (MW 4500-5500) \| Stavudine \| Ampicillin sodium \| Sulfamethoxazole sodium \| Kanamycin sulfate \| Sodium 4-phenylbutyrate
相關(guān)庫(kù)	經(jīng)典已知活性庫(kù) \| 抗癌活性化合物庫(kù) \| 植物來源化合物庫(kù) \| 生物堿類天然產(chǎn)物庫(kù) \| 古代經(jīng)典名方目錄分子庫(kù) \| 藥食同源庫(kù) \| 抗癌天然產(chǎn)物庫(kù) \| 天然產(chǎn)物庫(kù) \| 高通量篩選天然產(chǎn)物庫(kù) \| 抗感染天然產(chǎn)物庫(kù)

關(guān)鍵字：白鮮堿|||Dictamnine|||Dectamine|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國(guó)（陶術(shù)生物）

VIP 12年

公司成立：12年
注冊(cè)資本：566.2651萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫(kù)，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

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