Human IFN-alpha / beta R1 Protein, His Tag (MALS verified)

分子別名（Synonym）

IFNAR1,IFNAR,CRF2-1,IFN-R-1,IFNAR-1

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human IFN-alpha / beta R1 Protein, His Tag (IF1-H5225) is expressed from human 293 cells (HEK293). It contains AA Lys 28 - Lys 436 (Accession # P17181-1).

Predicted N-terminus: Lys 28

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 49.0 kDa. The protein migrates as 65-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

干擾素α/β受體1（IFNAR1）也稱為細(xì)胞因子受體II類成員1、細(xì)胞因子受體家族2成員1（CRF2-1）、I型干擾素受體1、IFNAR，屬于II型細(xì)胞因子受體族。IFNAR1/IFNAR包含四個纖維連接蛋白III型結(jié)構(gòu)域。IFNAR1與IFNAR2結(jié)合形成I型干擾素受體。IFNAR1是干擾素α和β的受體。IFNAR1可以在沒有IFNAR2的幫助下轉(zhuǎn)導(dǎo)IFNB信號，并且不會激活Jak-STAT通路。