中文名：LY2409881 trihydrochloride
英文名：LY2409881 trihydrochloride
英文別名：2-(5-chloro-2-(3-(4-methylpiperazin-1-yl)propylamino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride
純度：97%
貨號：L413816
包裝：100mg、5mg、25mg
Cas號：946518-60-1
存儲溫度：-20°C儲存
產(chǎn)品介紹：
Information
LY2409881 is a potent and selectiveIKK2inhibitor withIC50of 30 nM, >10-fold selectivity over IKK1 and other common kinases.
Targets
IKK2 30 nM
In vitro
LY2409881 inhibits constitutively activated NF-?B, and causes concentration- and time-dependent growth inhibition and apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. In the ovarian cancer cell line SKOV3, LY2409881 demonstrates moderate cytotoxicity. LY2409881 is synergistic with doxorubicin and cyclophosphamide in SUDHL2 cell in inhibiting the cell growth, but not in LY1 cell. In both SUDHL2 and LY1 cells, LY2409881 is synergistic with the histone deacetylase (HDAC) inhibitor romidepsin in inhibiting the cell growth.
In vivo
In SCID-beige xenograft mouse model, LY2409881 (50, 100, and 200 mg/kg, i.p.) signi?cantly inhibits the tumor growth.
Cell Research(from reference)
Cell lines：OCI-LY10 cells?
Concentrations：25 μM?
Incubation Time：~72 h?
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關(guān)鍵字： 2-(5-chloro-2-(3-(4-methylpiperazin-1-yl)propylamino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride
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