中文名：歐前胡素

英文名：Imperatorin

中文別名：前胡內(nèi)酯|白芷乙素|前胡素|8-(3-甲基-2-丁烯氧基)補骨脂素|8-異戊烯氧基補骨脂素|白茅苷|9-[(3-甲基-2-丁烯-1-基)氧]-7H-呋喃并[3,2-g]色滿-7-酮

英文別名：IMPERATORIN|482-44-0|Ammidin|Marmelosin|Pentosalen|8-Isoamylenoxypsoralen|8-Isopentenyloxypsoralene|Marmelide|NSC 402949|9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one|CCRIS 4346|HSDB 3497|9-(3-Methylbut-2-enyloxy)furo(3,2-g)chromen-7-one|EINECS 207-581-

純度：10mM in DMSO

貨號：I424190

包裝：1ml

Cas號：482-44-0

存儲溫度：-80℃儲存

產(chǎn)品介紹：

屬呋喃香豆素類化合物。為棱柱狀結(jié)晶（由乙醚）、長細針晶（由熱水），易溶于氯仿，可溶于苯、乙醇、乙醚和苛性堿溶液，不溶于冷水。Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been suggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway.

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