成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Cyclopamine,Cyclopamine
  • Cyclopamine,Cyclopamine

4449-51-8Cyclopamine

價(jià)格 詢價(jià)
包裝 1盒
最小起訂量 1盒
發(fā)貨地 上海
更新日期 2024-11-06
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:Cyclopamine英文名稱:Cyclopamine
CAS:4449-51-8品牌: 一研
保存條件: Store at -20°C產(chǎn)品類別: 抑制劑
Cas : 4449-51-8
2024-11-06 Cyclopamine Cyclopamine 1盒/RMB 一研 Store at -20°C 抑制劑

產(chǎn)品屬性:

產(chǎn)品名稱

規(guī)格

CAS號(hào)

型號(hào)

Cyclopamine

5mg 10mg 25mg 500mg 1g

4449-51-8

EY-Y0164738

Cas No.4449-51-8

別名 11-Deoxojervine

化學(xué)名 (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol

分子式 C27H41NO2

Cyclopamine.png

分子量 411.62

溶解度 6.9mg/mL in DMSO

儲(chǔ)存條件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述:
Cyclopamine is a naturally occurring Hedgehog (Hh)?specific small?molecule signaling steroidal alkaloid inhibitor, causes a profound inhibition of tumor growth, has significant anti?invasive, anti?proliferative and anti?estrogenic potency in human breast cancer cells [2] [1]. The EC50 of cyclopamine is 10.57 μM, it was identified by an FXR-bla (farnesoid X receptor- b-lactamase) assay [3].

Hh signaling pathway plays a critical role in embryonic development and tumorigenesis [4]. Hh signaling pathway shows saliency in regulating cellular proliferation and differentiation in a wide array of human tissues. It is related to aberrant cell survival in numerous human malignancies, ranging from BCCs and medulloblastomas to small cell lung, gastrointestinal, breast and prostate tumors [1].

Treated with cyclopamine (10 or 20 μM) only and incubated for time periods ranging from 0 to10 days, MCF-7 cells and MDA?MB?231 cells displayed a significant reduction in proliferation rate compared with the control cells on days 3 and 6 (P<0.01). In the MCF?7 cells, cyclopamine significantly induced cell accumulation in the G1 phase (P<0.01) and a modest decrease in the S population percentage, from 22 to 16% (P<0.01). In the MDA?MB?231 cells, cyclopamine caused a significant increase in G1 cells. The invasion rate of cyclopamine?treated MCF?7 and MDA?MB?231cells significantly decreased compared with the CK [2].

Embryoes exposed to cyclopamine resulted in visible external defects, including cyclopia, proboscis formation, microphthalmia, thoracic lordosis, amelia and decreased body size. Examination of gastrointestinal organs revealed severe deficits, including less length of the gut tube and mesenchymal cell numbers in foregut-derived organs. Ectopic structures in duodenum, stomach, and dorsal pancreas were also found [5].

References:

[1].  Marc J. Meth and Jeffrey M. Weinberg. Cyclopamine: Inhibiting Hedgehog in the Treatment of Psoriasis. Continuing Medical Education, 2006, 78: 185-188.

[2].  Jun Che, Fu-Zheng Zhang, Chao-Qian Zhao, et al. Cyclopamine is a novel Hedgehog signaling inhibitor with significant anti?proliferative, anti?invasive and anti?estrogenic potency in human breast cancer cells. Oncology Letters, 2013, 5: 1417-1421.

[3].  Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, et al. Quantitative High-Throughput Profiling of Environmental Chemicals and Drugs that Modulate Farnesoid X Receptor. Scientific Reports, 2014, 4: 6437.

[4].  Robert J. Lipinski, Paul R. Hutson, Paul W. Hannam, et al. Dose- and Route-Dependent Teratogenicity, Toxicity, and Pharmacokinetic Profiles of the Hedgehog Signaling Antagonist Cyclopamine in the Mouse. Toxicological Sciences, 2008, 104(1):189-197.

[5].  Seung K. Kim and Douglas A. Melton. Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor. Proc. Natl. Acad. Sci. USA, 1998, 95: 13036-13041.


關(guān)鍵字: 4449-51-8;C27H41NO2;Cyclopamine;

公司簡(jiǎn)介

上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學(xué)、分子生物學(xué)和常規(guī)生化試劑等為一體的科研產(chǎn)品銷售企業(yè),公司自成立以來(lái),秉承""全心全意服務(wù)于科研工作者""的企業(yè)理念,立足生物科技領(lǐng)域,運(yùn)用生物技術(shù)和科研試劑,發(fā)展現(xiàn)代生物科技,為各類大中小醫(yī)院及其它醫(yī)療機(jī)構(gòu)、高等院校、科研院所、企事業(yè)單位提供優(yōu)質(zhì)的產(chǎn)品,服務(wù)生物科技領(lǐng)域的科學(xué)研究人員。 公司具有對(duì)普通貨物、冷藏及冷凍倉(cāng)庫(kù)的存儲(chǔ)、包裝及運(yùn)輸能力。 公司將始終堅(jiān)持信譽(yù)立業(yè)、以人為本、質(zhì)量保證、誠(chéng)信服務(wù)的宗旨,不斷拼搏,開拓進(jìn)取,與各界朋友攜手共創(chuàng)美好未來(lái)。
成立日期 2014-06-05 (11年) 注冊(cè)資本 100
員工人數(shù) 50-100人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 生化試劑,抗體,細(xì)胞培養(yǎng),分子生物學(xué),免疫安全 經(jīng)營(yíng)模式 工廠,試劑
  • 上海一研生物科技有限公司
VIP 2年
  • 公司成立:11年
  • 注冊(cè)資本:100
  • 企業(yè)類型:營(yíng)業(yè)執(zhí)照
  • 主營(yíng)產(chǎn)品:、ELISA試劑盒、PCR檢測(cè)試劑盒、生化檢測(cè)試劑盒、標(biāo)準(zhǔn)品、抗體、細(xì)胞等
  • 公司地址:上海市閔行區(qū)莘福路2號(hào)樓
詢盤

4449-51-8Cyclopamine相關(guān)廠家報(bào)價(jià)

更多
產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥280.00
VIP13年
南京春秋生物工程有限公司
2024-11-05
¥1317.90
VIP13年
上海阿拉丁生化科技股份有限公司
2024-10-31
詢價(jià)
VIP6年
南京道斯夫生物科技有限公司
2024-10-31
詢價(jià)
VIP16年
上海佰世凱化學(xué)科技有限公司
2024-10-28
詢價(jià)
VIP4年
武漢艾美捷科技有限公司
2024-10-16
¥450
VIP3年
上海莫奇生物科技有限公司
2024-10-13
詢價(jià)
南京百鑫德諾生物科技有限公司
2024-09-26
詢價(jià)
VIP5年
陜西締都醫(yī)藥化工有限公司
2024-09-24
¥484
VIP12年
上海陶術(shù)生物科技有限公司
2024-09-23
詢價(jià)
上海西格生物科技有限公司
2024-03-28
內(nèi)容聲明:
以上所展示的信息由商家自行提供,內(nèi)容的真實(shí)性、準(zhǔn)確性和合法性由發(fā)布商家負(fù)責(zé)。 商家發(fā)布價(jià)格指該商品的參考價(jià)格,并非原價(jià),該價(jià)格可能隨著市場(chǎng)變化,或是由于您購(gòu)買數(shù)量不同或所選規(guī)格不同而發(fā)生變化。最終成交價(jià)格,請(qǐng)咨詢商家,以實(shí)際成交價(jià)格為準(zhǔn)。請(qǐng)意識(shí)到互聯(lián)網(wǎng)交易中的風(fēng)險(xiǎn)是客觀存在的