中文名稱
5Z,8Z,11Z,14Z-二十碳四烯酸,2-甘油酯; 2-AG; 2-花生四烯酸甘油
英文名字
5Z,8Z,11Z,14Z-eicosatetraenoic acid, 2-glyceryl ester; 2-AG; 2-Arachidonoyl Glycerol
供應(yīng)商
開曼生物
產(chǎn)品貨號
62160-1
產(chǎn)品報價
¥1015.8/1mg
產(chǎn)品說明書
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購買方式
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產(chǎn)品新聞
背景資料
2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the CB1 receptor. Unlike anandamide, 2-AG is present at relatively high levels in the central nervous system; it is the most abundant molecular species of monoacylglycerol found in rat brain. Formation of 2-AG is calcium-dependent and is mediated by the activities of PLC and DAG lipase. 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism. 2-AG is metabolized in vitro by MAG lipase and fatty acid amide hydrolase, with MAG lipase likely being the principle metabolizing enzyme in vivo.
產(chǎn)品描述
An analog of arachidonic acid in which the carboxyl group is replaced by a trifluoromethyl ketone group; inhibits the activity of the 85 kDa cPLA2 and the 80 kDa macrophage iPLA2 without altering the activity of the 14 kDa sPLA2s; at a concentration of 7.5 uM, almost completely inhibits hydrolysis of AEA in a rat brain homogenate
保存建議
建議您在收到開曼生物品牌的2-Arachidonoyl Glycerol (1 mg)產(chǎn)品后置于-80度保存,產(chǎn)品有效期為180天.
其他
開曼生物向全球科學(xué)工作者提供多研究領(lǐng)域的生化、免疫試劑和分析試劑盒,其產(chǎn)品被廣泛應(yīng)用于腫瘤、氧化氮、神經(jīng)學(xué)、凋亡、氧化性損傷、內(nèi)分泌學(xué)等不同研究領(lǐng)域.開曼生物可提供用于檢測的特色試劑盒,如:類花生酸類物質(zhì)、游離的生物標(biāo)志、環(huán)核苷、激素及氧化氮等;也提供多種高質(zhì)量試劑,包括:類花生酸類物質(zhì)、氧化氮試劑及許多相關(guān)脂質(zhì)、脂肪酸、酶和抗體.作為開曼生物在中國的區(qū)域總代理,艾美捷科技有限公司將為中國客戶提供最全面的開曼生物產(chǎn)品以及客戶訂制化服務(wù).
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