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一、中文名稱:Anti-Human TSHR/LGR3 Antibody (M22)(FHD18110),抗人促甲狀腺素受體
二、產(chǎn)品描述
促甲狀腺素受體(Thyrotropin receptor, TSHR)是一種細(xì)胞表面糖蛋白受體,屬于A類G蛋白偶聯(lián)受體(GPCRs)超家族的LGR亞家族,并與Gs蛋白相連接。TSHR主要在甲狀腺組織中表達(dá),但其mRNA和蛋白也存在于神經(jīng)組織、免疫細(xì)胞、眼肌、骨骼、脂肪細(xì)胞、紅細(xì)胞、卵巢和肝臟等部位。TSHR接受促甲狀腺激素(Thyrotropin, TSH)信號(hào)刺激后,啟動(dòng)偶聯(lián)信號(hào)通路,促進(jìn)下游效應(yīng)基因的表達(dá),刺激細(xì)胞生成甲狀腺激素(T4)和三碘甲狀腺激素(T3),對(duì)甲狀腺的生長(zhǎng)和功能至關(guān)重要。
三、產(chǎn)品詳情
名稱:Anti-Human TSHR/LGR3 Antibody (M22) (FHD18110)
別名:hyroid-stimulating hormone receptor, TSH-R, TSHR, Thyrotropin receptor, LGR3, RHD18102
貨號(hào):FHD18110
種屬反應(yīng)性:Human
宿主:Human
同種型:IgG1
克隆類型:Monoclonal
偶聯(lián)物:Unconjugated
靶標(biāo):Thyroid-stimulating hormone receptor, TSH-R, TSHR, Thyrotropin receptor, LGR3
濃度:1 mg/ml
內(nèi)毒素水平:Please contact with the lab for this information.
純度:>95% as determined by SDS-PAGE.
純化方式:Protein A/G purified from cell culture supernatant.
Accession號(hào):P16473
克隆號(hào):M22
應(yīng)用:FCM
狀態(tài):Liquid
保存溶液:0.01M PBS, pH 7.4.
穩(wěn)定性和存儲(chǔ):Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Mechanisms of Action of TSHR Autoantibodies. PMID: 26361260
Modulation of TSHR signaling by posttranslational modifications. PMID: 17524661
Central Tolerance Mechanisms to TSHR in Graves' Disease: Contributions to Understand the Genetic Association. PMID: 30396220
TSHR-based chimeric antigen receptor T cell specifically deplete auto-reactive B lymphocytes for treatment of autoimmune thyroid disease. PMID: 37690235
Controversial constitutive TSHR activity: patients, physiology, and in vitro characterization. PMID: 24845969
Genetics of Graves' Disease: Special Focus on the Role of TSHR Gene. PMID: 26361261
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