Product Details
| Product Name:
Gossypin |
CAS No.:
652-78-8 |
| Purity:
98.97% |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Gossypin |
| 描述 | Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activation pathway, which may explain its role in the suppression of inflammation, carcinogenesis, and angiogenesis. |
| 體外活性 | Gossypin is a flavone extracted from Hibiscus vitifolius, which has been reported to exhibit anti-inflammatory, antioxidant, and anticancer activities.?However, the anticancer properties of gossypin and its molecular mechanism of action against gastric cancer have not been fully investigated.?gossypin is an Aurora kinase A (AURKA) and RSK2 inhibitor that suppresses gastric cancer growth.?Gossypin attenuated anchorage-dependent and anchorage-independent gastric cancer cell growth as well as cell migration.?Based on the results of in vitro screening and cell-based assays, gossypin directly binds to and inhibits AURKA and RSK2 activities and their downstream signaling proteins.?Gossypin decreased S phase and increased G2/M phase cell cycle arrest by reducing the expression of cyclin A2 and cyclin B1 and the phosphorylation of the CDC protein.?Additionally, gossypin also induced intrinsic apoptosis by activating caspases and PARP and increasing the expression of cytochrome c. Gossypin is an AURKA and RSK2 inhibitor that could be useful for treating gastric cancer[2]. |
| 存儲(chǔ)條件 | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 25 mg/mL (52.04 mM)
|
| 關(guān)鍵字 | Antiinflammatory | inhibit | Nuclear factor-κB | Inhibitor | Antioxidant | Anticancer | cardiovascular,osteoclastogenesis | Antiallergic | NF-κB | Nuclear factor-kappaB | Gossypin | Antiviral | Analgesic |
| 相關(guān)產(chǎn)品 | Sodium Houttuyfonate | Zingerone | Lidocaine | α-Lipoic Acid | Diethylmaleate | Glucosamine | sodium lauroyl-α-hydroxyethyl sulfonate | Lidocaine hydrochloride | 5-Aminosalicylic Acid | Indole-3-carbinol | Diallyl disulfide | Sodium salicylate |
| 相關(guān)庫 | 黃酮類天然產(chǎn)物庫 | 疼痛相關(guān)化合物庫 | 經(jīng)典已知活性庫 | 中藥單體化合物庫 | 抑制劑庫 | 高通量篩選天然產(chǎn)物庫 | 已知活性化合物庫 | 古代經(jīng)典名方目錄分子庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$890.00/1g |
VIP1Y
|
R&D Scientific Inc.
|
2024-03-31 |
United States