Sp-Cyclic AMPS (sodium salt) NEW
| Price | $170 | $755 |
| Package | 1mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-01 |
Product Details
| Product Name: Sp-Cyclic AMPS (sodium salt) | CAS No.: 142439-95-0 |
| Supply Ability: 10g | Release date: 2025/05/01 |
Product Introduction
Bioactivity
| Name | Sp-Cyclic AMPS (sodium salt) |
| Description | Sp-cAMPS sodium salt is an analog of cAMP that serves as a potent activator of cAMP-dependent PKA I and PKA II, and as a competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 μM. It also binds the PDE10 GAF domain with an EC50 of 40 μM [1] [2] [3]. |
| In vitro | The glucagon-stimulated increases in the level of Ca 2+ can be mimicked by Sp-cAMPS. Treatment of hepatocytes with Sp-cAMPS which is the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with glucagon [4]. |
| In vivo | In chronic alcohol consumption (CAC) mice, direct infusion of the PKA activator (Sp-cAMPS) (1 μg/μL) into the prefrontal cortex significantly improves working memory performance in withdrawn animals and impairs it in water animals [5]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | SpCyclic AMPS (sodium salt) | Sp Cyclic AMPS (sodium salt) | Sp-Cyclic AMPS |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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