Factory Provide 5-Aminosalicylic Acid CAS 89-57-6 Mesalazine

Introduction

Product Name :  5-Aminosalicylic Acid

Other name:;2-HYDROXY-5-AMINOBENZOIC ACID;3-Carboxy-4-hydroxyaniline;5-AMINO-2-HYDROXYBENZOIC ACID;

CAS No.: 89-57-6

MF:C7H7NO3

MW:153.14

Appearance: White powder 

Melting Point :275-280 °C (dec.) (lit.)

Boiling Point :276.03°C (rough estimate)

Density :1.3585 (rough estimate)

Storage :Sealed in dry,Store in freezer, under -20°C

Mesalazine, also known as 5-aminosalicylic acid, is an organic compound with the chemical formula C7H7NO3 and is the active ingredient in SASP for the treatment of ulcerative colitis. It has a significant inhibitory effect on intestinal wall inflammation. Mesalazine can inhibit the synthesis of inflammatory prostaglandins and the formation of inflammatory mediums leukotriene, which can significantly inhibit the inflammation of intestinal mucosa. Mesalazine inhibited prostaglandin synthesis and PGE2 release in human colon mucosa in a dose-dependent manner.

Mesalazine is an anti-inflammatory agent, structurally related to the salicylates, which is active in inflammatory bowel disease. It is considered to be the active moiety of sulphasalazine. A study of the therapeutic properties of sulfasalazine and its constituents[mesalazine (5-amino salicylic acid, 5-ASA) and sulfapyridine] indicated that mesalazine is the therapeutically active component, while sulfapyridine acts as an inert carrier molecule to facilitate delivery to the colon. This discovery, coupled with the implication of sulfapyridine in most of the adverse events associated with sulfasalazine treatment, led to the development of Mesalazine as a pure therapeutic entity.

Function
Uses The active metabolite of Sulfasalazine (S699084). Anti-inflammatory (gastrointestinal).
Uses anesthetic (local)
Uses peroxidase substrate
Uses For the treatment of active ulcerative proctitis.
Uses In manufacture of light-sensitive paper, azo and sulfur dyes.