5-Aminosalicylic Acid NEW
| Price | $45 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-28 |
Product Details
| Product Name: 5-Aminosalicylic Acid | CAS No.: 89-57-6 |
| Purity: 98.88% | Supply Ability: 10g |
| Release date: 2025/04/28 |
Product Introduction
Bioactivity
| Name | 5-Aminosalicylic Acid |
| Description | 5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. |
| In vivo | At 2 mM, Mesalamine or sulfasalazine significantly reduces the expression of TC22 transcript and reversibly inhibits the expression of TC22 protein in a dose-dependent manner. Mesalamine induces the membrane expression of E-cadherin protein, enhancing intercellular adhesion. It also regulates the glycosylation of E-cadherin, elevating the mRNA and protein levels of GnT-III. In the range of 0.1-1 mM, Mesalamine dose-dependently suppresses chemiluminescence mediated by peroxynitrite, suggesting its ability to directly scavenge peroxynitrite. Only at a higher concentration, 1 mM, does Mesalamine inhibit both the hydroxyl radical adduct formation and the concurrent movement in electron paramagnetic resonance spectra. It inhibits 3-hydroxysteroid dehydrogenase involved in the reversible conversion between DHP and THP, potentially affecting the local effects of DHP and THP in the brain. Furthermore, Mesalamine suppresses the phosphorylation of RelA triggered by IL-1. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 29 mg/mL (189.37 mM), Sonication is recommended. DMSO : 60 mg/mL (391.8 mM), Sonication is recommended. |
| Keywords | PPARγ | PPAR | Peroxisome proliferator-activated receptors | PAK | p21 activated kinases | Nuclear factor-κB | Nuclear factor-kappaB | NF-κB | NFκB | NF-kB | NFkB | MPO | Inhibitor | inhibit | GlutathionePeroxidase | Glutathione Peroxidase | EndogenousMetabolite | Endogenous Metabolite | COX | ALOX5 | 5-Aminosalicylic Acid | 5Aminosalicylic Acid | 5 Aminosalicylic Acid |
| Inhibitors Related | Sucrose | Acetaminophen | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Pain-Related Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Natural Product Library for HTS | FDA-Approved Drug Library | FDA-Approved Kinase Inhibitor Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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