5-Aminosalicylic Acid NEW
| Price | $45 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: 5-Aminosalicylic Acid | CAS No.: 89-57-6 |
| Purity: 99.98% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | 5-Aminosalicylic Acid |
| Description | 5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. |
| In vivo | At 2 mM, Mesalamine or sulfasalazine significantly reduces the expression of TC22 transcript and reversibly inhibits the expression of TC22 protein in a dose-dependent manner. Mesalamine induces the membrane expression of E-cadherin protein, enhancing intercellular adhesion. It also regulates the glycosylation of E-cadherin, elevating the mRNA and protein levels of GnT-III. In the range of 0.1-1 mM, Mesalamine dose-dependently suppresses chemiluminescence mediated by peroxynitrite, suggesting its ability to directly scavenge peroxynitrite. Only at a higher concentration, 1 mM, does Mesalamine inhibit both the hydroxyl radical adduct formation and the concurrent movement in electron paramagnetic resonance spectra. It inhibits 3-hydroxysteroid dehydrogenase involved in the reversible conversion between DHP and THP, potentially affecting the local effects of DHP and THP in the brain. Furthermore, Mesalamine suppresses the phosphorylation of RelA triggered by IL-1. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 29 mg/mL (189.4 mM) DMSO : 60 mg/mL (391.8 mM) |
| Keywords | 5-Aminosalicylic Acid | NF-κB | Nuclear factor-κB | 5 Aminosalicylic Acid | PAK | Inhibitor | Peroxisome proliferator-activated receptors | p21 activated kinases | inhibit | PPAR | Nuclear factor-kappaB | 5Aminosalicylic Acid | Endogenous Metabolite |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Natural Product Library | Anti-Cancer Approved Drug Library | FDA-Approved Kinase Inhibitor Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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