5-Aminosalicylic Acid NEW
| Price | $45 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-27 |
Product Details
| Product Name: 5-Aminosalicylic Acid | CAS No.: 89-57-6 |
| Purity: 98.88% | Supply Ability: 10g |
| Release date: 2025/04/27 |
Product Introduction
Bioactivity
| Name | 5-Aminosalicylic Acid |
| Description | 5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. |
| In vivo | At 2 mM, Mesalamine or sulfasalazine significantly reduces the expression of TC22 transcript and reversibly inhibits the expression of TC22 protein in a dose-dependent manner. Mesalamine induces the membrane expression of E-cadherin protein, enhancing intercellular adhesion. It also regulates the glycosylation of E-cadherin, elevating the mRNA and protein levels of GnT-III. In the range of 0.1-1 mM, Mesalamine dose-dependently suppresses chemiluminescence mediated by peroxynitrite, suggesting its ability to directly scavenge peroxynitrite. Only at a higher concentration, 1 mM, does Mesalamine inhibit both the hydroxyl radical adduct formation and the concurrent movement in electron paramagnetic resonance spectra. It inhibits 3-hydroxysteroid dehydrogenase involved in the reversible conversion between DHP and THP, potentially affecting the local effects of DHP and THP in the brain. Furthermore, Mesalamine suppresses the phosphorylation of RelA triggered by IL-1. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 29 mg/mL (189.37 mM), Sonication is recommended. DMSO : 60 mg/mL (391.8 mM), Sonication is recommended. |
| Keywords | PPARγ | PPAR | Peroxisome proliferator-activated receptors | PAK | p21 activated kinases | Nuclear factor-κB | Nuclear factor-kappaB | NF-κB | NFκB | NF-kB | NFkB | MPO | Inhibitor | inhibit | GlutathionePeroxidase | Glutathione Peroxidase | EndogenousMetabolite | Endogenous Metabolite | COX | ALOX5 | 5-Aminosalicylic Acid | 5Aminosalicylic Acid | 5 Aminosalicylic Acid |
| Inhibitors Related | Sucrose | Acetaminophen | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Pain-Related Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Natural Product Library for HTS | FDA-Approved Drug Library | FDA-Approved Kinase Inhibitor Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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