BMH-21
| 中文名稱 | BMH-21 |
|---|---|
| 中文同義詞 | N-[2-(二甲基氨基)乙基]-12-氧代-12H-苯并[G]吡啶并[2,1-B]喹唑啉-4-甲酰胺;RNA POLYMERASE I轉(zhuǎn)錄抑制劑(BMH-21);N-(2-(二甲氨基)乙基)-12-氧代-12H-苯并[G]吡啶并[2,1-B]喹唑啉-4-甲酰胺;BMH 21,RNA聚合酶I抑制劑 |
| 英文名稱 | BMH21 |
| 英文同義詞 | BMH21;N-[2-(dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide;BMH-21 N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide;N-[2-(Dimethylamino)ethyl]-12-oxo-2H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide;CS-1749;BMH 21;BMH21;BMH-21, >98%;12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide, N-[2-(dimethylamino)ethyl]-12-oxo- |
| CAS號(hào) | 896705-16-1 |
| 分子式 | C21H20N4O2 |
| 分子量 | 360.41 |
| EINECS號(hào) | 809-833-1 |
| 相關(guān)類別 | 小分子抑制劑，天然產(chǎn)物;小分子抑制劑;細(xì)胞生物學(xué)試劑;醫(yī)藥;Inhibitors |
| Mol文件 | 896705-16-1.mol |
| 結(jié)構(gòu)式 |  |
BMH-21 性質(zhì)
| 密度 | 1.28±0.1 g/cm3(Predicted) |
|---|---|
| 儲(chǔ)存條件 | 2-8°C |
| 溶解度 | DMSO：可溶1mg/mL，澄清（加熱） |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 7.90±0.20(Predicted) |
| 顏色 | 淡黃色至深黃色 |
BMH-21是一種DNA嵌入劑，與核糖體DNA結(jié)合，并抑制RNA polymerase I (Pol I)轉(zhuǎn)錄。BMH-21 causes proteasome-dependent destruction of RPA194, the large catalytic subunit protein of Pol I holocomplex. In U2OS cancer cell line, BMH-21 results in degradation of RPA194 and translocation of NCL with IC50 of 0.05 μM and 0.07 μM, respectively. By causing nucleolar stress, BMH-21 also shows potent inhibition on cell viability.BMH-21 reduces tumor growth in mouse xenografts.