展青霉素（Patulin,PTL)又稱展青霉毒素、棒曲霉素、珊瑚青霉毒素，是一種有毒的真菌代謝產(chǎn)物,其具有廣譜的抗生素特點(diǎn)。然而，由于它的毒性作用，研究人員已不再繼續(xù)其作為治療用途藥物的研究。
Patulin (Terinin) 是由 Aspergillus、Penicillium 和 Byssochlamys 幾種真菌屬產(chǎn)生的霉菌毒素，被認(rèn)為有致染色體斷裂、突變，致畸和細(xì)胞毒性作用。Patulin 通過溶酶體-線粒體軸誘導(dǎo)自噬依賴性細(xì)胞凋亡，能引起 DNA 損傷[1] sup>
用途
毒枝菌素，帶有抗細(xì)菌、抑制鉀吸收和可能的致癌活性。
用途
Patulin (PAT), a mycotoxin produced by certain species of Penicillium, Aspergillus, and Byssochlamys, is mainly found in ripe apple and apple products.
glutathione in Hep G2 cells. Patulin is an antibiotic. Patulin-induced nephropathy and gastrointestinal tract malfunction have been demonstrated in several animal models. The oral LD50 value of patul
in ranges between 29 and 55 mg/kg body weight in rodents and 170 mg/kg body weight in poultry. The World Health Organization considers patulin cytotoxic and established a safety level of patulin in ap
ple juice at 50 μM. At 100-200 μM, patulin can directly increase intracellular oxidative stress in HEK293 and HL-60 cells. In 1944, this compound was tested in a clinical trial for potential antibiot
ic properties to treat the common cold.
類別
有毒物質(zhì)
毒性分級(jí)
劇毒
急性毒性
口服- 大鼠 LD50 27.79 毫克/ 公斤; 口服- 小鼠 LD50: 17 毫克/公斤
可燃性危險(xiǎn)特性
可燃, 火場排出辛辣刺激煙霧
儲(chǔ)運(yùn)特性
庫房低溫, 通風(fēng), 干燥; 與食品原料分開存放
滅火劑
水, 二氧化碳, 干粉, 砂土
